РусскийEnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    A. P. Oshurko, I. Yu. Oliinyk

    STUDY OF THE QUALITATIVE CHARACTERISTICS OF THE MAXILLA BONE TISSUE ACCORDING TO THE QUANTITATIVE CONTENT OF MACROELEMENTS (P, NA, CA, MG, S) IN THE DYNAMICSOF PRENATAL ONTOGENESIS


    About the author: A. P. Oshurko, I. Yu. Oliinyk
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The germs of the maxillas of 131 fetuses in the age of 11-40 weeks of fetal development have been investigated in order to determine the quantitative macroelements (P, Na, Ca, Mg, S) content in the dynamics of prenatal ontogenesis. The bone tissue sampling was carried out on the both sides of the upper jaw germ of human fetuses from different areas, that had macroscopically the most marked density. A complex of methods of morphological research was applied, which included macroscopy, morphometry, fine preparation of objects under the control of loupe were used during the investigation; methods of flame atomic emission and atomic absorption analysis; photometric and turbidimetric methods; the method of statistical groupings in the study of qualitatively homogeneous aggregates, the variational analysis of statistical data with the calculation of average values for each macroelement, the errors of the average values, the reliability of the average values and the probability of accurate prognosis. A significant difference was found in the dynamics of the fetal period of prenatal ontogenesis between the indices of macroelements content, which is a qualitative result of quantitative morphology in determining their content during the study of the upper jaw bone tissue in human fetuses. The regularity of the dynamics of the upper jaw bone density of human fetuses, depending on the mineral content and the presence of the revealed synchronism of these processes, suggests that the change in density is the evidence of a change in the content of individual mineral elements, but the macroelements (Ca, P, Na, Mg, S), as the main building material are the most important. The obtained results are well-grounded and can be the basis for developing new methods of early diagnosis of congenital anomalies of the maxillofacial area in the preclinical stages of its development and methods of their prevention, by correcting the mineral content.
    Tags maxilla, prenatal ontogenesis, human, macroelements
    Bibliography
    • Boiechko FF,  Boiechko LO. Osnovni biokhimichni poniattia, vyznachennia i terminy. Kyiv. 1993. 528 s. [in Ukrainian]
    • Dzerzhynskyi ME, Vareniuk IM. Navchalnyi posibnyk dlia laboratornykh zaniat z velykoho morfometrychnoho spetspraktykuma dlia studentiv kafedry tsytolohii, histolohii ta biolohii rozvytku. Kyiv: Fitosotsiotsentr. 2006; 83 s. [in Ukrainian]
    • Krynytskyi RP. Analiz mineralnoho skladu kistkovoi tkanyny komirkovoi chastyny nyzhnoi shchelepy ta yoho vikovoi dynamiky u osib cholovichoi ta zhinochoi stati. Klinichna anatomiia ta operatyvna khirurhiia. 2015; 14(3): 40–43. [in Ukrainian]
    • Mishalov VD, Voichenko VV, Malysheva TA, Dibrova VA, Kuzyk PV, Yurchenko VT. Poriadok vyluchennia biolohichnykh obiektiv vid pomerlykh, tila yakykh pidliahaiut sudovo-medychnii ekspertyzi i patolohoanatomichnomu doslidzhenniu, dlia naukovykh tsilei: metodychni rekomendatsii. Osvita Ukrainy: spetsvypusk hazety. Kyiv: Pedahohichna presa. 2018; 2(62): 3–13. [in Ukrainian]
    • Oshurko AP, Oliinyk IYu, Hryshchuk HV. Perspektyvy vyvchennia yakisnykh ta kilkisnykh kharakterystyk kistkovoi tkanyny plodiv liudyny kombinovanymy ta hibrydnymy metodamy doslidzhennia. Visnyk problem biolohii i medytsyny. 2018;  2(144): 43–49. Doi: 10.29254/2077-4214-2018-2-144-43-49 [in Ukrainian]
    • Ponomarenko SI. Zviazok mizh parametramy stomatolohichnoho statusu ta systemnymy pokaznykamy stanu kistkovoi systemy. Problemy osteolohii. 2015;18(2):40–50. [in Ukrainian]
    • Sytnyk KM, Topachevskyi VO, redaktory. Biolohichnyi slovnyk.  Kyiv. 1986; 680 s. [in Ukrainian]
    • Slabyi BO. Kilkisna morfolohiia hipertrofovanoho sertsia. Visnyk naukovykh doslidzhen. 2017; 4: 6–9. [in Ukrainian]
    • Slobodian OM, Korchynska NS. Renthenanatomiia ta morfometriia verkhnoi shchelepy v druhomu trymestri vnutrishnoutrobnoho rozvytku.  Ukrainskyi zhurnal klinichnoi ta laboratornoi medytsyny. 2013; 8(3): 98–101. [in Ukrainian]
    • Chaikovska SYu. Analiz vikovoi dynamiky mineralnoho skladu kistkovoi tkanyny komirkovoi chastyny nyzhnoi shchelepy u ditei doshkilnoho viku. Klinichna anatomiia ta operatyvna khirurhiia. 2016; 15(3): 53–57. [in Ukrainian]
    • Ferros IN, Mora MJ, Obeso IF, Jimenez P, Martinez-Insua A. The nasomaxillary complex and the cranial base in artificial cranial deformation: relationships from a geometric morphometric study. Eur. J. Orthod. 2015 Aug; 37(4): 403–411.
    • Govindraju P, Chandra P. Radiomorphometric indices of the mandible – an indicator of osteoporosis. J. Clin. Diagn. Res. 2014; 8(3): 195–198.
    • Oshurko AP, Oliinyk IYu. Features of morphogenesis of the maxillofacial area in the embryonic and pre-fetal periods of human prenatal ontogenesis. In:  Development and modernization of medical science and practice: experience of Poland and prospects of Ukraine: Collective monograph. Vol. 1. Lublin: Izdevnieciba “Baltija Publishing”. 2017; 203–236.
    • Szpinda M, Baumgart M, Szpinda A, Woz´niak A, Mila-Kierzenkowska C, Dombek M, et al. Morphometric study of the T6 vertebra and its three ossification centers in the human fetus. Surg. Radiol. Anat. 2013; 35: 901–916.
    • Xiaochen F, Loebel DAF, Bildsoe H, Wilkie EE, Qin J, Wang J, et al. Tissue interactions, cell signaling and transcriptional control in the cranial mesoderm during craniofacial development. AIMS Genetics. 2016; 3(1): 74–98.
    Publication of the article «World of Medicine and Biology» №1(67), 2019 year, 171-177 pages, index UDK 611.716.1.018.4.013-053.13/.15
    DOI 10.26724/2079-8334-2019-1-67-171