English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Yu.В. Chaikovsky

    HYPERVASCULARISATION OF REGENERATIVE NEUROMA


    About the author: Yu.В. Chaikovsky
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Although the post-traumatic morphological changes as well as those taking place in the course of nerve trunks regeneration have been extensively studied, there are few quantitative data on nerve fibers and microvessels of the regenerative neuroma. This study is aimed at obtaining the morphometric data on nerve fibers and capillaries of the regenerative neuroma of the rats’ sciatic nerve 3, 6, 12 and 24 weeks after neurotomy. The study has revealed a significant increase in the density of capillaries and nerve fibers in regenerative neuroma at the initial stages of the experiment. By 24 weeks after surgery, these indicators were normalized. It may be concluded that hypervascularisation of the regenerative neuroma of the peripheral nerve after its injury provides for the metabolic and plastic needs of regenerating axons and connective tissue cells.
    Tags regenerative neuroma, sciatic nerve, hypervascular, rats
    Bibliography
    • Blinkov SM, Moiseyev GD. Opredeleniye plotnosti kapillyarnoy seti v organakh i tkanyakh cheloveka i zhivotnykh nezavisimo ot tolshchiny mikrotomnogo sreza. Doklady AN SSSR. 1961; 140 (2): 465-8. [in Russian]
    • Korsak A.V., Chaykovskiy YuB. Immunogistokhimicheskiy analiz stroyeniya nevromy travmirovannogo perifericheskogo nerva posle operativnogo lecheniya s primeneniyem elektrokhirurgicheskogo instrumenta v rezhime svarivaniya Byulleten eksperimentalnoy biologii i meditsiny. 2015; 159(6): 769-72. [in Russian]
    • Alzate O. Neuroproteomics. Boca Raton (FL): CRC Press; 2010. Chapter 15, Applications of Proteomics to Nerve Regeneration Research; p. 122-44.
    • Chung AM. Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration. Reviews of Neuroscience. 2018; 29(4): 369-376.
    • Coleman MP, Freeman MR. Wallerian Degeneration, Wld, and Nmnat. Annual Reviews of Neuroscience. 2010; 33: 245-67.
    • Court FA, Midha R, Cisterna BA, Grochmal J, Shakhbazau A, Hendriks WT, et al. Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons. Glia. 2011; 59(10): 1529-39.
    • Fairbairn NG, Meppelink AM, Glazier J, Randolph MA,Winograd JM. Augmenting peripheral nerve regeneration using stem cells: A review of current opinion. World Journal of Stem Cells. 2015; 7(1): 11-26.
    • Faroni A, Mobasseri SA, Kingham PJ, Reid AJ. Pertipheral nerve regeneration: Experimental strategies and future perspectives. Advanced Drug Delivery Reviews. 2015; 82-83: 160-7.
    • Freeman MR. Signaling mechanisms regulating Wallerian degeneration. Current Opinions in Neurobiology. 2014; 9: 224-31.
    • Klimovskaya AI, Сhaikovsky YB, Naumova OV, Vysotskaya, NA, Korsak AV, Likhodiievskyi VV, et al. Coulomb interactions at the interface silicon wire-nervous tissue. Світ медицини та біології. 2016; 1: 134-9.
    • Lopez-Leal R, Court FA. Schwann сell exosomes mediate neuron-glia communication and enhance axonal regeneration. Cellular and Molecular Neurobiollogy.2016; 36(3): 429-36.
    • Lopez-Verrilli MA, Picou F, Court FA. Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system. Glia. 2013; 61(11):1795-806.
    • Sherman DL, Brophy P.J. Mechanisms of axon ensheathment and myelin growth. Nature Reviews. Neuroscience. 2005; 6: 683-90.
    • Vasyliev RG, Rodnichenko AE, Shamalo SN, Demidchouk AS, Labunets IF, Chaikovsky Y.B, et al. Effects of neural crest-derived multipotent stem cells on the regeneration of an injured peripheral nerve in mice Neurophysiology. 2015; 47(1): 80-3.
    • Zheng JQ, Kelly TK, Chang B, Ryazantsev S, Rajasekaran AK, Martin KC, et al. A Functional Role for Intra-Axonal Protein Synthesis during Functional Regeneration of Adult Sensory Neurons. The Journal of Neuroscience. 2001; 21(23): 9291-303.
    Publication of the article «World of Medicine and Biology» №1(67), 2019 year, 200-203 pages, index UDK 616.833-089.84-07:616.16-031:611.89
    DOI 10.26724/2079-8334-2019-1-67-200