Article
ANTIBODIES TO ANTI-CCP, RHEUMATOID FACTOR AND MARKERS OF INFLAMMATION, AS THE MAIN DIAGNOSTIC PARAMETERS IN PATIENTS WITH RHEUMATOID ARTHRITIS
| About the author: | Zhdan V.N., Tkachenko M.V., Babanina M.Yu., Zherebkin V.V., Kitura Ye.M., Volchenko G.V. |
| Heading | CLINICAL MEDICINE |
| Type of article | Scentific article |
| Annotation | Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology, characterized by chronic inflammation of the joints, which leads to tissue deformation of the joints. The course of RA is diverse, ranging from light form to a possible aggressive form. Early diagnosis and treatment reduce joint damage, permitting a patient to maintain functioning and improve survival. The relationship between chronic inflammation and joint damage has been established and widely covered, in particular, the relevance of such inflammatory markers as the rate of erythrocyte sedimentation (ESR) and C-reactive protein (CRP). However, damage can progress, despite the decrease in the activity of the inflammatory process and erosion may develop in patients without clinical manifestations of significant inflammation. Thus, the definition of reliable predictors and markers of joint damage is definitely essential and important. The purpose of the present study was to compare the diagnostic value of laboratory parameters active rheumatoid arthritis: matrix metaloproteinazy-3 (MMP-3), antibodies to cyclic citrullinated anti-peptide (anti-CCP), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in patients with erosive and noterosive forms of rheumatoid arthritis. In the survey group was involved patients, consisting of 60 patients with RA, the diagnosis of which meets the revised criteria of the American College of Rheumatology. Enzymatic Assay (ELISA) was used to determine the anti-MMP-CCPta 3.RF determined using a latex strengthening imunonotfelometrycal analysis. CRP was measured using a latex immunoassay. The levels of antibody titers for anti-CCP and ESR were significantly higher in patients with erosive RA than in patients with RA noterosive (p < 0.001 and 0.0341), respectively. Moreover, a higher frequency of high titers of antibodies to anti-CCP has been found in patients with erosive RA compared to patients with RA noterosive (78.3% vs. 43.2%, respectively). ROC curve for anti-CCP passes near the upper near left corner than the other markers and area under the curve anti-CCP was much larger than the area under the curve of other markers (0.755 for anti-CCP, 0,660 for ESR, 0.611 for CRP, 0,577 for RF and 0.484 MMP-3 for women). The positive predictive value was higher for antibodies to anti-CCP compared with other markers. We found no significant statistical correlation between antibody titers for anti-CCP and inflammatory markers such as CRP or ESR. However, we have confirmed the correlation of high antibody titers for anti-CCP and RF in both groups of patients, while the degree of correlation was more significant in patients with RA noterosive. Our results indicate that the presence of high titers of antibodies to anti-CCP has better diagnostic value compared to MMP-3, RF, CRP and ESR in patients with erosive RA. |
| Tags | rheumatoid factor, antibodies for anti-CCP, C-reactive protein, erythrocyte sedimentation rate, rheumatoid arthritis |
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| Publication of the article | «World of Medicine and Biology» №2(68), 2019 year, 044-048 pages, index UDK 616.72 – 002.77. – 085 |
| DOI | 10.26724/2079-8334-2019-2-68-44-48 |