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    Shulhai A-M.A., Pavlyshyn H.A.

    LEVELS OF VITAMIN D AND CARDIOMETABOLIC RISK FACTORS IN OBESITY ADOLESCENTS


    About the author: Shulhai A-M.A., Pavlyshyn H.A.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The growth in the number of adolescents with obesity is an important global problem. The aim of the work was to examine the relationship between the levels of vitamin D and proatherogenic cardiometabolic risk factors in adolescents with obesity. 168 adolescents with obesity were examined. The average age of teenagers was 15.1 ± 2.1 years. None of the adolescents had obesity due to endocrine diseases. Parameters that were determined in all children included: undertaking anthropometric measurements, general examinations, biochemical parameters, including lipid metabolism, fasting glucose, insulin, measuring the homeostasis model assessment for insulin resistance, blood pressure measurement and determination of vitamin D status. Among all adolescents, vitamin D deficiency was defined in 75.6 % and insufficiency in 20.3 %. Conforming to the 2007 International Diabetes Federation criteria metabolic syndrome was diagnosed in 57.2 % in adolescents with obesity. All results were processed using statistical analysis. It showed the inverse correlations between vitamin D level and body mass index, waist circumference, levels of low-density lipoprotein cholesterol, total cholesterol, systolic blood pressure and insulin levels. There were no statistically significant associations of calcidiol with triglycerides, high-density lipoprotein cholesterol and fasting blood sugar levels. The most frequent proatherogenic metabolic risk factors occur when obesity is combined with vitamin D deficiency. The obtained results permitted to make the following conclusions: 1. In children of adolescence with obesity in 75.6% deficiency is defined, and in 20.3% insufficiency of vitamin D. 2. In obesity, which is accompanied by insufficiency and deficiency of vitamin D, the indices of proatherogenic metabolic disorders increase, insulin resistance increases and the content of high density lipoprotein cholesterol, which provides antiatherogenic properties, decreases. 3. It has been found that 25 (OH) D has a reversible probable relationship with body mass index, waist circumference, systolic blood pressure, low density lipoprotein cholesterol, total cholesterol, and basal insulin. 4. In adolescents, obesity is accompanied by the development of metabolic syndrome, which is more often manifested in boys. Vitamin D deficiency contributes to an increase in the number of cardiometabolic risk factors. Prospects for further research lie in developing adequate methods for the treatment of obesity and metabolic syndrome, which are combined with D hypovitaminosis.
    Tags vitamin D, metabolic syndrome, children, obesity, cardiometabolic disorders
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    Publication of the article «World of Medicine and Biology» №2(68), 2019 year, 148-153 pages, index UDK 616.391:577.161.2:516.1:616-008.9-056.52]-053.6
    DOI 10.26724/2079-8334-2019-2-68-148-153