N.M. Brechka, V.P. Nevzorov, N. Yu. Seliukova, E.M. Koreneva, E. V. Shcherbak

CYTOSTATIC IMPACT ON SPERMATOGENIC CELLS ULTRASTRUCTURE AND ITS CORRECTION BY CHONDROITIN SULPHATE

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About the author:	N.M. Brechka, V.P. Nevzorov, N. Yu. Seliukova, E.M. Koreneva, E. V. Shcherbak
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	The article presents data on the specific changes in the animal spermatogenic cells ultrastructure under the impact of doxorubicin hydrochloride. It is shown that the toxic effect of cytostatics is accompanied by the development of dystrophic and destructive changes in the rat testes cells. Under the influence of chondroitin sulfate, the gradual restoration of reparative processes in the rat spermatogenic cells exposed to doxorubicin hydrochloride was carried out. Chondroitin sulfate facilitated the turnover of the structure of the filaments plasmatic membrane areas after the toxic effect of the cytostatic, which ensures normal sperm motility.
Tags	testes ultrastructure, spermatogenesis, chondroitin sulfate, cytostatics, doxorubicin hydrochloride
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Publication of the article	«World of Medicine and Biology» №2(68), 2019 year, 171-174 pages, index UDK 591.463.2: 615.277.3: 616-08
DOI	10.26724/2079-8334-2019-2-68-171-174