| About the author: |
І. І.Yuryk, P. Ya. Bodnar, Ya. Ya. Bodnar, Yu. M. Orel |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study was performed with the purpose to study the features of cross-striated muscles remodeling of the femoral, knee and lower leg areas of the hind limbs in rats of pre-reproductive and reproductive age under conditions of experimental hypercholesterolemia. It was established that remodeling of muscle fibers in all terms of the experiment was manifested by loss of striation, homogenization, sarcoplasmolysis with myocytolysis and contracture changes. Submicroscopically degenerative and destructive changes of mitochondria, cytoplasm vacuolation, pycnosis of hemocapillar endotheliocytes’ nucleoplasm were observed. The most significant remodeling occurs in the cross-striated muscles of reproductive age animals in the lower leg area, in animals of pre-reproductive age - in the femoral and knee areas. |
| Tags |
hypercholesterolemia, remodeling, skeletal muscles, contracture changes, myocytolysis |
| Bibliography |
- Bahriy MM, DibrovaVA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Vinnytsya: Nova Knyha; 2016. 328 s. [in Ukrainian]
- Klymenko VM, Baldin IA. Revaskulyarizatsiya nyzhnikh kintsivok pry krytychniy ishemiyi. Materialy KHKHIII zyizdu khirurhiv Ukrayiny; 2015, zhovtnya 21-23; Kyiv. 2015. [Internet]: Dostupno na: http://surgery.org.ua/data/ upload / content / main / ua / mainPage / program_zyzdu_21-23.10.2015.pdf [in Ukrainian]
- Krepkova LV. Ispolzovaniye modeli giperlipidemii i ateroskleroza u krys v toksikologicheskom eksperimente. Biomeditsina. 2011;3:103-6. [in Russian]
- Nikulnykov PI, Bytsay AN, Yatsenko AI. Mezhdystsyplinarnyi podkhod k lecheniyu patsiyentov s okklyuzionno-stenotycheskim porazheniem arterialnykh sosudov nizhnikh konechnostey. Materialy XXIII zyizdu khirurhiv Ukrayiny; 2015, zhovtnya 21-23; Kyiv. 2015. [Internet]: Dostupno na: http://surgery.org.ua/data/ upload / content / main / ua / mainPage / program_zyzdu_21-23.10.2015.pdf [in Russian]
- Piskun RP, HrynchakNM. Osoblyvosti mikromorfometrychnykh zmin struktur sertsya pry eksperymentalnomu aterosklerozi ta yoho hennoyi korektsiyi. Visnyk problem biolohiyi ta medytsyny. 2011; 2 (3): 147-50. [in Ukrainian]
- Polyakov LM, Lushnykova EL, Nepomnyashchykh LM, Ruskykh HS, Byushkina NKh, Klynnikova MH. ta in. Pokaznyky metabolizmu lipidiv ta bilkovoho skladu lipoproteyiniv plazmy krovi hipotyreoyidnykh shchuriv pry eksperymentalniy hiperkholesterynemiyi. Fundamentalni doslidzhennya. 2014; 10: 342-5. [in Ukrainian]
- Chernіak VA. Surgery of critical ischemia of the lower extremities. Heart and blood vessels. 2013;1:54-63.
- Gardner AW, Parker DE, Montgomery PS, Khurana A, Ritti-Dias RM, Blevins SM. Gender differences in daily ambulatory activity patterns in patients with intermittent claudication. J. Vasc. Surg. 2010 Nov;52(5):1204-10.
- Hirsch AT, Duval S. The global pandemic of peripheral artery disease. Lancet. 2013 Oct 19;382(9901):1312-4.
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| Publication of the article |
«World of Medicine and Biology» №2(68), 2019 year, 215-219 pages, index UDK 616.748–003.93–06:616.153.922]–092.9 |
| DOI |
10.26724/2079-8334-2019-2-68-215-219 |
