| About the author: |
V.Yu. Kassich, V.V. Ukhovskyi, O.I. Sosnytskyi, I.A. Biben, V.V. Zazharsky, O.V. Kassich |
| Heading |
BIOLOGY |
| Type of article |
Scentific article |
| Annotation |
For adaptation, selection and accumulation of production strains bacterial mass, Sotona KF and Sotona-KhB growth media were developed, where cultures of M. bovis begin to grow earlier by (4.2 1.1) days and give more bacterial mass accumulated. New technological procedures of manufacturing PPD-tuberculin by means of microfiltration and ultracentrifugation methods have been developed, permitting to obtain an active and specific allergen. A method for sensitization of experimental animals by inactivated M. bovis culture has been developed to perform the control study of the drug. The method is specific, safe for the health of animals and humans, it prevents the spread of living mycobacteria in nature. |
| Tags |
tuberculosis, mycobacteria, PPD-tuberculin, membrane microfiltration, ultracentrifugation |
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| Publication of the article |
«World of Medicine and Biology» №2(68), 2019 year, 220-225 pages, index UDK 619:616:98:579.873.21:631.153.7 |
| DOI |
10.26724/2079-8334-2019-2-68-220-225 |
