EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Dubyna V.A., Skrypnykov P.N., Khavalkina, L.M., Korobeinikova Yu.L.

    SUBSTANTIATION OF USE OF NANOPREPARATION IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS OF I-II DEGREE


    About the author: Dubyna V.A., Skrypnykov P.N., Khavalkina, L.M., Korobeinikova Yu.L.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation Currently, periodontal disease is rating first among dental diseases. Among all known treatment methods, in complex therapy the leading one is local therapeutic treatment with various preparations, the choice of which should be based on the degree and form of the pathology and severity of the course of chronic generalized periodontitis (CGP). In our study we used nanopreparation called Fullerene-C60. Good tolerability and safety of the preparation in treatment of CGP allows us to consider it as a non-injectable alternative to conventional methods of treatment. The nanopreparation was used in the irrigator and in the form of instillations / applications (or their combination) in each periodontal pocket. The area of protein fractals before and after administration of Fullerene-C60 has been studied. The findings of the study showed that the protein fractal area in two groups decreased on the average by 2.480%. The use of Fullerene-C60 in the form of irrigation and instillation / applications showed a clear decrease in the area of protein fractals in tiziographic samples, which proves the rational use of this nanopreparation.
    Tags Fullerene-C60 nanopreparation, periodontitis, biofilm
    Bibliography
    • Dubina VA, Khavalkina LM,. Silenko BYu [y dr] Perspektivy ispolzovanyia nanopreparatov v stomatologii. American Journal of Science and Technologies. 2016; 1 (21): 1070–1079. [in Russian]
    • Komarnitskiy BM. Vliyaniye zubnykh irrigantov na mikrobiotsenoz polosti rta [dissertatsiya]. Mоskva. 2005: 24 s. [in Russian]
    • Malyk NYe. Estimation of dynamics of changes of species composition of periodontal pockets microflora in patients with chronic generalized periodontitis using polymerase chain reaction. Actual problems of modern medicine: Bulletin of the Ukrainian Medical Dental Academy. 2010; 1:155–157.
    • Mykhaylov AA, vynakhidnyk. Sposib zaboru zubnoho nalyotu z dilyanok odnakovoyi ploshchi poverkhni zubiv abo neznimnykh zubnykh proteziv. Patent Ukrayiny 68133. 2012 ber.12. [in Ukrainian]
    • Orekhova LYu, Zhavoronkova MD, Suborova TN. Sovremennyye tekhnologii bakteriologicheskogo issledovaniya parodontalnykh prostranstv. Parodontologiya. 2013; 2: 9–13. [in Russian]
    • Rebrova O. Yu. Statisticheskiy analiz meditsinskikh dannykh. Primeneniye paketa prikladnykh programm STATISTICA. Moskva: MediaSfera, 2002. 266 s. [in Russian]
    • PM Skrypnykov, LM Khavalkina, Dubyna VO, vynakhidnyky. Sposib likuvannya khronichnoho heneralizovanoho parodontytu I ta II stupeniv tyazhkosti iz zastosuvannyam nanopreparatu «Fulleren S60». Patent Ukrayiny 125525. 2017 hrud.20. [in Ukrainian]
    • Donald RM, Costerton JW. Biofilm: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002; 5(2):167–193.
    Publication of the article «World of Medicine and Biology» №3(69), 2019 year, 063-066 pages, index UDK 616.314.17-085
    DOI 10.26724/2079-8334-2019-3-69-63-66