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    Kravets O.V., Protsyk V.S., Burtyn O.V., Khlynin O.V., Gurianov V.G

    PRIMARY SURGERY VERSUS CHEMORADIOTHERAPY IN PATIENTS WITH STAGE III-IV ORAL SQUAMOUS CELL CARCINOMA


    About the author: Kravets O.V., Protsyk V.S., Burtyn O.V., Khlynin O.V., Gurianov V.G
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The paper offers a comparative analysis of the treatment outcomes in patients with stages III-IV resectable oral squamous cell carcinoma. The overall and disease-free five-year survival rates in individuals who had undergone primary surgery with adjuvant radiotherapy (RT) chemoradiotherapy (CRT) were 55.4% and 59.6%, respectively, whereas in patients receiving definitive CRT, they were 18.9% and 15.2%. The comparison of the overall and disease-free survival curves revealed a statistically significant ((p <0.001) and (p <0.001)) higher overall and disease-free survival in patients undergoing primary surgery with adjuvant RT or CRT as compared with those having definitive CRT (HR = 0.32 (95% BI 0.25 - 0.41) and (HR = 0.23 (95% BI 0.18 - 0.30). The multivariable analysis showed that the prognosis of the overall and disease-free survival rates was statistically significantly affected by the primary tumour extent, cervical lymph node involvement and treatment modality.
    Tags oral squamous cell carcinoma, surgical treatment, radiotherapy, chemoradiotherapy
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    Publication of the article «World of Medicine and Biology» №3(69), 2019 year, 077-082 pages, index UDK 616.31-006.6-085.277.3-085.849.1
    DOI 10.26724/2079-8334-2019-3-69-77-82