| About the author: |
Maslova G.S., Skrypnyk I.M. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Timely evaluation of liver functional disorders tests and their correct interpretation is of particular importance during specific chemotherapy, as well as during the patients’ recovery after cytostatic treatment. The article presents the results of the authors’ own studies on 16 patients with chronic lymphoproliferative diseases of low-grade malignancy who died in the hematology department of Poltava M.V. Sklyfosovsky Regional Clinical Hospital. A comparative evaluation of hematological and biochemical panel parameters depending on the presence of the liver tumor infiltration according to pathohistological examination. It has been shown that liver tumor infiltration is associated with peripheral blood leukocytosis (p<0.05) and increased serum alkaline phosphatase activity (p<0.05). The results obtained permit to make the following conclusions. Liver tissue infiltration occurs in 75% of patients with B-chronic lymphocytic leukemia and in 33.3% of patients with B-cell chronic lymphocytic leukaemia and multiple myeloma. Peripheral blood hyperleukocytosis and increased serum alkaline phosphatase activity can be considered as a risk factor for liver tumor infiltration. |
| Tags |
chronic lymphoproliferative diseases, tumor liver infiltration, biochemical liver tests |
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| Publication of the article |
«World of Medicine and Biology» №3(69), 2019 year, 113-118 pages, index UDK 616.36-006-071:615.28 |
| DOI |
10.26724/2079-8334-2019-3-69-113-118 |
