EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Yeroshenko G.А., Koptev М.М., Bilash S.М., Shevchenko K.V., Yachmin А.І.

    RESTRUCTURING OF RAT LUNGS IN ACUTE IMMOBILIZATION STRESS AND ITS CORRECTION


    About the author: Yeroshenko G.А., Koptev М.М., Bilash S.М., Shevchenko K.V., Yachmin А.І.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Currently, the search for advanced effective and safe methods of preventing and treatment of stress disorders is one of the priority tasks of medical science. The paper was aimed at the morphological study of the corrective effect of torasemide on rat lungs in experimental acute immobilization stress compared to the stress-protective effect of mexidol. Taking into account the norms of bioethics, the study was involved 30 mature albino male rats. Group І (controls) (n=10) involved animals, exposed to stress without correction; Group II (n=10) involved rats, exposed to stress after administration of mexidol; Group III (n=10) involved rats, exposed to stress that was corrected with torasemide. Correction with pharmacological drugs, especially torasemide, reduces stress effect on the lungs. Histologically, torasemide contributes to retention of the epithelial lining integrity, local visualization of intra-alveolar erythrocytes, and plethora in the capillaries of the interalveolar septa. In the epithelial lining of the bronchi, desquamation of individual cells was sometimes observed. The findings of the study have shown that torasemide has a pronounced stress-protective effect on the lung tissue, which is more powerful than correction with mexidol.
    Tags lungs, stress, correction, torasemide, mexidol, morphology
    Bibliography
    • Bahriy MM, DibrovaVA, redaktory. Metodyky morfolohichnykh doslidzhen: monohrafiya. Vinnytsya: Nova knyha; 2016. 328 s. [in Ukrainian]
    • Vazhnycha OM. Antystresorna diya pirydoksynu yak proyav yoho farmakodynamichnoyi aktyvnosti. Farmakolohiya ta likar. toksykolohiya. 2012; 6. 3-7. [in Ukrainian]
    • Devyatkina TO, Vazhnycha OM, Vlasenko NO. Stresorni mekhanizmy hostroyi krovovtraty ta yikh farmakolohichna korektsiya v eksperymenti. Visnyk problem biolohiyi i medytsyny. 2017; 144(4, 3):117-22. [in Ukrainian]
    • Zakon Ukrayiny «Pro zakhyst tvaryn vid zhorstokoho povodzhennya» № 3447–IV vid 21.02.2006. Kyiv; 2006. 18 s. [in Ukrainian]
    • Karnaukh YeV. Antistressovoye kardioprotektornoye deystviye piratsetama pri emotsionalnom stresse po kriteriyu ogranicheniya stress-indutsirovannoy fermentemii i proteoliza. Yeksperimental'na í klíníchna meditsina. 2013; (1):43-46. [in Russian]
    • Lutsenko RV, Devyatkina TO. Antyoksydantni vlastyvosti n-(1-naftyl) amid-2-oksoindolin-3-hlioksylovoyi kysloty pry hostromu stresi. Visnyk problem biolohiyi i medytsyny. 2012; 94(3, 1):74-7. [in Ukrainian]
    • Merkulov G.A. Kurs patogistologicheskoy tekhniki. Leningrad: Meditsina; 1969. 424 s. [in Russian]
    • Neporada KS, Slobodyanyk NM. Vplyv melaninu na rozvytok oksydatyvnoho stresu v pidshlunkoviy zalozi shchuriv zalezhno vid stresostiykosti orhanizmu. Patolohiya. 2011; 8 (2): 59-61. [in Ukrainian]
    • Omelchenko OYe, Tarasenko LM, Devyatkina TO, vynakhidnyky; Ukrayinska medychna stomatolohichna akademiya, patentovlasnyk. Sposib korektsiyi ultserohennoho efektu hostroho stresu u shchuriv. Patent Ukrayiny № 58721. 26 Kvit 2011. [in Ukrainian]
    • Shkurupiy OA. Eksperymentalne obhruntuvannya rozvytku nekardiohennoho nabryaku lehen u khirurhichnykh khvorykh pry obmezheniy rukhoviy aktyvnosti. Visnyk problem biolohiyi i medytsyny. 2015; 125(4, 2):68-70. [in Ukrainian]
    • European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of Europe, Strasbourg; 1986. 53 p.
    • Koptev MM, Vynnyk NI. Morphological substantiation for acute immobilization stress-related disorders of adaptation mechanisms. Wiadomosci lekarskie. 2017;70(4):767-70.
    • Lutsenko RV, Vakhnenko AV, Vlasova EV. Research of the protection actions of derived 2-oxoindole in acute stress. Wiadomosci lekarskie. 2017;70(1):57-61.
    • Lutsenko RV, Sydorenko AH, Bobyriov VM. Anhedonia at experimental models of chronic stress and its correction. Wiadomosci lekarskie. 2017;70(4):745-750.
    • Pronina ОМ, Koptev MM, Bilash SM, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. Світ медицини та біології. 2018; 63(1):153-7.
    Publication of the article «World of Medicine and Biology» №3(69), 2019 year, 187-190 pages, index UDK 611.24-06:616.45-001.1/3-026.374-036.11]-018-092.9:616-08
    DOI 10.26724/2079-8334-2019-3-69-187-190