Kovalska M.Ye., Zhukovsky V.S., Baida M.L.

CHANGES OF SPECIFIC INDICES OF PROOXIDATIVE AND ANTIOXIDANT SYSTEMS IN TIMUS OF ANIMALS IN EXPERIMENTAL ALERGETIC ALVEEOLITE IN STRESS CONDITIONS AND THEIR CORRECTION

---

About the author:	Kovalska M.Ye., Zhukovsky V.S., Baida M.L.
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	The performed studies showed that in the experimental AA before treatment with Corvitin, the processes of lipid peroxidation and antioxidant system in the thymus are activated, the results of the experimental AA model before treatment with Corvitin give grounds to assert the development of the imbalance between the prooxidant and antioxidant systems, in particular the gradual suppression of the antioxidant defense of the body in female guinea pigs and significant activation of lipid peroxidation processes in the experimental AA before treatment with Corvitin. To correct LPO and AOS parameters in group VIII of the experimental AA model under the conditions of immobilization stress (thirty-fourth day) treatment with Corvitin was carried out, which was administered intraperitoneally at the dose of 40 mg / kg (the drug “Corvitin”, Borshchagovsky Chemical-Pharmaceutical Plant), which led to the decrease in the formation of lipid peroxidation and AOS products in the thymus, having decreased compared to animals with the combined pathology, which were injected with the antioxidant Corvitin. The obtained research results allow us to speak about the corrective effect of Corvitin on the indices of the prooxidant and antioxidant systems in the thymus during experimental AA under conditions of immobilization stress and make it possible to recommend this antioxidant for further studies.
Tags	experimental allergic alveolitis, immobilization stress, thymus, corvitin
Bibliography	Boykiv DP, Bodnarchuk TI, Ivankiv OL, ta in. Biokhimichni pokaznyky v normi i pry patolohiyi. Kyiv: Medytsyna; 2007. 318 s. [in Ukrainian] Gavrilov VB, Mishkorudnaya MI. Spektrofotometricheskoye opredeleniye soderzhaniya gidroperekisey lipidov v plazme krovi. Laboratornaya diagnostika ishemicheskoy bolezni serdtsa. K.: Zdorovye; 1989. 170-171. [in Russian] Gorizontov, PD, Belousova OI, Fedotova MI. Stress i sistema krovi. M. Meditsina; 1983. 239 s. Kolb VG, Kamyshnikov VG. Opredeleniye aktivnosti tseruloplazmina v krovi . Spravochnik po klinicheskoy khimii. Minsk Belarus; 1982. 290–291. [in Russian] Korobeynikova EN. Modifikatsiya opredeleniya produktov POL v reaktsii s tiobarbiturovoy kislotoy. Lab. Delo. 1989; 7: 8-10. [in Russian] Orekhov OO, Kirilov YuA. Patomorfologiya legkikh i mikrotsirkulyatornogo rusla malogo kruga krovoobrashcheniya pri khronicheskom eksperimentalnom allergicheskom alveolite. Arkhiv patologii.1985; 10: 54–61. [in Russian] Porivnyalni dani pro rozpovsyudzhennya khvorob orhaniv dykhannya i medychnu dopomohu khvorym na khvoroby pulmonolohichnoho ta alerhichnoho profilyu v Ukrayini za 2006-2013rr. Kyiv, 2013 Natsionalna akademiya medychnykh nauk Ukrayiny. Tsentr medychnoyi statystyky MOZ Ukrayiny derzhavna ustanova « Natsionalnyy instytut ftyziatriyi i pulmonolohiyi im.F.H. Yanovskoho NAMN Ukrayiny». Kyiv; 2013. [in Ukrainian] Fried R. Enzymatic and non-enzymatic assay of super oxide dismutase. Biochemie. 1975; (57): 65, 657-660. Holmes, R, Masters C, et al. Epigenetic interconversions of the multiple forms of mouse liver catalase. FEBS Lett. 1970; (11) 1: 45-48. Ivanov KP. Brain hypoxia and the role of active forms of oxygen and of energy deficit in the neuron degeneration. Usp. Fiziol. Nauk 2012; 43 (1): 95-110. Komarovaa NS, Krivenkoa AG, Ryabenkoa AG, Naumkinb AV. Active forms of oxygen as agents for electrochemical functionalization of SWCNTs. Carbon; 2013; 53: 188-196. Trujilloa J, Chirinob YI, Molina-Jijónc E, Andérica-Romeroa AC, Tapiad E, PedrazaChaverría J Renoprotective effect of the antioxidant curcumin: Recent findings. 2013; 1(1):: 448-456.
Publication of the article	«World of Medicine and Biology» №3(69), 2019 year, 191-193 pages, index UDK 616.24-002-008.6-056.3+612.014.484)-019-092:612.438.015.11]-085.274
DOI	10.26724/2079-8334-2019-3-69-191-193