| About the author: |
Veresnyuk N.S., Pyrohova V.I., Piniazhko O.B. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Dysmenorrhea is the most common gynecological problem in women which negatively affects patients’ quality of life. The present study compared the efficacy and analized the average cost of Vitex agnus-castus and mefenamic acid in the treatment of dysmenorrhea in women with non-obstructive congenital uterus anomalies. This double-blind clinical trial was carried out in 42 women who were randomly divided into two groups. Dysmenorrhea severity by VAS and quality of life by SF-12 were assessed at baseline and three menstrual cycles throughout the treatment. It was found that at the end of the treatment, VAS scores were significantly fell in both groups compared to before intervention values (P<0.05) but at the first month the improvement in pain was more significant in the mefenamic acid group in comparison to the Vitex agnus-castus group (3.8 vs 2.5; P=0.0417). There was a remarkable improvement in quality of life in both groups. At the end of treatment by Vitex agnus-castus SF-12 sum-score was 88.4±11.2 vs 94.8±10.2; P=0.0300) and after mefenamic acid it was 85.7±12.5 vs 92.5±11.2; P=0.0354. It was found that the cost of dysmenorrhea’s treatment with mefenamic acid was on 94.6% lower versus Vitex agnus-castus. Our results showed that Vitex agnus-castus was as effective as mefenamic acid in decreasing the pain severity of dysmenorrhea in women with reproductive tract congenital anomalies and promoted as same as mefenamic acid a significant improvement in quality of life. But the use of mefenamic acid in treatment of dysmenorrhea is economically beneficial. |
| Tags |
dysmenorrhea, quality of life, Vitex agnus-castus, mefenamic acid |
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| Publication of the article |
«World of Medicine and Biology» №4(70), 2019 year, 035-039 pages, index UDK 618.14-007.24+618.175)-085.276-085.322+614.27 |
| DOI |
10.26724/2079-8334-2019-4-70-35-39 |
