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    Kuzminova N.V., Romanova V.O., Sierkova V.K., Lukyantseva H.V., Osovska N.Yu., Knyazkova I.I., Havrylyuk A.O., Marchak T.V.

    COMPARATIVE ASSESSMENT OF THE EFFICACY OF ADDITIONAL ENDOTHELIAL-PROTECTIVE THERAPY IN PATIENTS WITH CORONARY HEART DISEASE


    About the author: Kuzminova N.V., Romanova V.O., Sierkova V.K., Lukyantseva H.V., Osovska N.Yu., Knyazkova I.I., Havrylyuk A.O., Marchak T.V.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation To study the efficacy of additional appointment of endothelial-protective therapy, depending on the variant of coronary heart disease (CHD) course, 43 patients were examined. All subjects additionally to standard basic therapy received a fixed combination of meldonium (180 mg) with gamma-butyrobetaine (60 mg) orally 2 capsules twice daily for 4 weeks. Depending on the CHD variant patients were divided into 2 groups. The first group (n=22) included patients with stable CHD course, the second group (n=21) was consisted from patients with unstable angina. The parameters were evaluated before the prescription of therapy and 1 month after its initiation. Complex treatment (basic therapy plus fixed combination of meldonium with gamma-butyrobetaine) resulted in a significant (p<0.05) improvement of both clinical status of CHD patients and functional state of endothelium (vasomotor and adhesive functions). Moreover, significantly (p<0.05) more pronounced results were obtained in patients with unstable angina. Thus, an addition of a fixed combination of meldonium with gamma-butyrobetaine to standard therapy for patients with coronary heart disease has a significant endothelial-protective effect and contributes to the disease stabilization.
    Tags coronary heart disease, unstable angina, endothelial dysfunction, meldonium, gamma-butyrobetaine
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    Publication of the article «World of Medicine and Biology» №4(70), 2019 year, 107-112 pages, index UDK 616-005.4-08
    DOI 10.26724/2079-8334-2019-4-70-107-112