| About the author: |
Kuzminova N.V., Romanova V.O., Sierkova V.K., Lukyantseva H.V., Osovska N.Yu., Knyazkova I.I., Havrylyuk A.O., Marchak T.V. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
To study the efficacy of additional appointment of endothelial-protective therapy, depending on the variant of coronary heart disease (CHD) course, 43 patients were examined. All subjects additionally to standard basic therapy received a fixed combination of meldonium (180 mg) with gamma-butyrobetaine (60 mg) orally 2 capsules twice daily for 4 weeks. Depending on the CHD variant patients were divided into 2 groups. The first group (n=22) included patients with stable CHD course, the second group (n=21) was consisted from patients with unstable angina. The parameters were evaluated before the prescription of therapy and 1 month after its initiation. Complex treatment (basic therapy plus fixed combination of meldonium with gamma-butyrobetaine) resulted in a significant (p<0.05) improvement of both clinical status of CHD patients and functional state of endothelium (vasomotor and adhesive functions). Moreover, significantly (p<0.05) more pronounced results were obtained in patients with unstable angina. Thus, an addition of a fixed combination of meldonium with gamma-butyrobetaine to standard therapy for patients with coronary heart disease has a significant endothelial-protective effect and contributes to the disease stabilization. |
| Tags |
coronary heart disease, unstable angina, endothelial dysfunction, meldonium, gamma-butyrobetaine |
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| Publication of the article |
«World of Medicine and Biology» №4(70), 2019 year, 107-112 pages, index UDK 616-005.4-08 |
| DOI |
10.26724/2079-8334-2019-4-70-107-112 |
