| About the author: |
Syzova L.M., Koval L.T., Bodnar V.A., Kaydashev I.P., Izyumska O.М. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
A cross-sectional study of 166 patients with chronic hepatitis C was carried out. As a result of the analysis, among the 35 possible factors of rapid progression of hepatic fibrosis in chronic hepatitis C, 10 most informative ones were identified: male gender (p=0.005), 1 genotype of HCV (p=0.040), alanine aminotransferase above 3 upper limits of normal (p=0.015), the levels of aspartate aminotransferase, γ-glutamyltranspeptidase and total bilirubin exceeding the upper limit of normal (p=0.000, p=0.000 and p=0.001, respectively), alcohol consumption >40 g/day (p=0.033), chronic cholecystitis and/or pancreatitis (p=0.000), type II diabetes mellitus (p=0.007) and a carriage of the normal genotype (Gln/Gln, Gln/-) of the TLR7 gene (p=0.001). In order to optimize the prognostication of the affiliation of a patient with chronic hepatitis C to the risk group of rapid progression of hepatic fibrosis there were proposed the highly effective mathematical model, developed on the basis of multiple discriminant analysis, exact forecast of which was 82.5 %. |
| Tags |
chronic hepatitis C, the rate of fibrosis progression, prognostic model, discriminant analysis |
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| Publication of the article |
«World of Medicine and Biology» №4(70), 2019 year, 151-155 pages, index UDK 616.36-006.327-036-06:616.36-002.14/2:612.6.05 |
| DOI |
10.26724/2079-8334-2019-4-70-151-155 |
