| About the author: |
Ostrovskyi M.M., Deltsova O.І., Gevka O.I., Herashchenko S.B. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In the study of the subtle structure of the peripheral nerve in the correction of paclitaxel-induced neuropathy with armadine, it was established that, restoration of experimental paclitaxel-induced neuropathy in the peripheral nerve occurs in 3 periods. The first period lasts up to 28 days from and manifested by the restoration of the myelin nerve fibers. Among them there are demyelinated nerve fibers with destruction of the axial cylinder, their Schwann cells are vacuolated, the endoneurium is swollen. On the 21st-28th days the condition of mitochondria is normalized. Morphological signs of increased protein synthesis are present in Schwann cells. A small amount of damaged myelin nerve fibers remains. Characteristic of the third period are the newly formed nerve fibers of small and medium caliber with normal state of morphological structures. The number of nerve fibers of large caliber with signs of dystrophic processes increases, progressing atrophy of axial cylinders, manifestations of failure of regenerative processes. |
| Tags |
paclitaxel, sciatic nerve, Armadin |
| Bibliography |
- Gevka OI. Patomorfohenez paklitaksel-indukovanoyi peryferiynoyi neyropatiyi. Svit medytsyny ta biolohiyi. 2014;2(44):105-10. [in Ukrainian]
- Dovha NZ. Ultrastrukturni zminy v sitkivtsi oka pry korektsiyi paklitaksel-indukovanoyi retynotoksychnosti antyoksydantnym preparatom. Ukrayinskyy zhurnal medytsyny, biolohiyi ta sportu. 2017;5(7):20-25. [in Ukrainian]
- Gevka OI. Electron microscopic changes of sciatic nerves in rats with experimental peripheral neuropathy caused by paclitaxel. PharmaInnJ. 2014; 3(1):36-48.
- Hanai A, Ishiguro H, Sozu T, Tsuda M, Yano , Nakagawa T et al. Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial. 2018; Natl Cancer Inst. 2018 Feb 1; 110(2):141-8.
- Matsui A, Tatibana A, Suzuki N, Hirata M, Oishi Y, Hamaguchi Y et al. Evaluation of Efficacy and Safety of Upfront Weekly Nanoparticle Albumin-bound Paclitaxel for HER2-negative Breast Cancer. Anticancer Res. 2017 Nov; 37(11):6481-8.
- Miao H, Xu J, Xu D, Ma X, Zhao X, Liu L. Nociceptive behavior induced by chemotherapeutic paclitaxel and beneficial role of antioxidative pathways. Physiol Res. 2019; 68(3): 491-500.
- Polomano RC, Mannes FJ, Clark US. A painful peripheral neuropathy in the rat prodiced by the chemotherapeutic drug, Paclitaxel. Pain. 2001; 94(3):293-304.
- Speck RM, DeMichele, Farrar JT. Scope of symptoms and self-management strategies for chemotherapy-induced peripheral neuropathy in breast cancer patients. Support Care Cancel. 2012; 20(10):2433-9.
- Stubblefield MD, McNeely MI, Alfano CM. A prospective survellance model for physical rehabilitation of women with breast cancer. Cancer. 2012; 118(8 Suppl):2250-60.
- Wozniak KM, Nomoto K, Lapidus RG. Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel and ixabepilone in mice. Cancer Res, 2011; 71(11):3952-62.
- Zheng H, Xiao WH, Bennett GJ. Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy. Exp Neurol, 2011; 232(2):154-61.
|
| Publication of the article |
«World of Medicine and Biology» №4(70), 2019 year, 218-223 pages, index UDK 616-092.9 + 615.28 + 616.85 + 615.27 |
| DOI |
10.26724/2079-8334-2019-4-70-218-223 |
