| About the author: |
Bilovol O.M., Kniazkova I.I., Bogun M.V., Lutsenko R.V. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The aim of the study was to improve the effectiveness of the treatment of arterial hypertension (AH) in young patients with clinical signs of autonomic dysfunction. We examined 65 male patients with AH (mean age 35.6 ± 4.3 years) and clinical signs of autonomic dysfunction. Basic therapy was administered to 30 of them (group 1), and ethylmethylhydroxypyridine succinate (EMS) was additionally administered to 35 patients (group 2) for 4 weeks. After treatment, BP correction to target values was achieved in 76.7% of the patients in group 1 and in 88.6% in group 2. On the background of therapy with EMS, a more pronounced increase in total HRV, decreased activity of the sympathetic division of the autonomic nervous system and restoration of the vegetative balance according to the temporal HRV indicators, as well as the significant positive changes in state and trait anxiety were observed. Thus, the inclusion of EMS in the complex treatment of young males with AH and clinical signs of autonomic dysfunction has a positive effect on clinical symptoms, contributes to the restoration of the autonomic balance and correction of psycho-emotional state. |
| Tags |
arterial hypertension in young, autonomic dysfunction, heart rate variability, anxiety, ethylmethylhydroxypyridine succinate |
| Bibliography |
- Azova MM, Blagonravov ML, Frolov VA. Effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats. Bull Exp Biol Med. 2015; 158(3):313-314.
- Carney EF. Succinate homeostasis protects against lithogenesis and hypertension. Nat Rev Nephrol. 2019; 15(5):255.
- Esler M. Mental stress and human cardiovascular disease. Neurosci Biobehav Rev. 2017; 74(Pt B):269-276.
- Garafova A, Penesova A, Cizmarova E, Marko A, Vlcek M, Jezova D. Cardiovascular and sympathetic responses to a mental stress task in young patients with hypertension and/or obesity. Physiol Res. 2014; 63 (4):459-67.
- Jarczewski J, Furgała A, Winiarska A, Kaczmarczyk M, Poniatowski A. Cardiovascular response to different types of acute stress stimulations. Folia Med Cracov. 2019; 59(4):95-110.
- Redina OE, Smolenskaya SE, Maslova LN, Markel AL. The genetic control of blood pressure and body composition in rats with stress-sensitive hypertension. Clin Exp Hypertens. 2013; 35(7):484-95.
- Sammito S, Böckelmann I. Options and limitations of heart rate measurement andanalysis of heart rate variability by mobile devices: A systematic review. Herzschrittmacherther Elektrophysiol. 2016; 27(1):38-45.
- Sanatani S, Cunningham T, Khairy P, Cohen MI, Hamilton RM, Ackerman MJ. The Current State and Future Potential of Pediatric and Congenital Electrophysiology. JACC Clin Electrophysiol. 2017; 3(3):195-206. 9.
- Thayer JF, Sollers JJ 3rd, Friedman BH, Koenig J. Gender differences in the relationship between resting heartrate variability and 24-hour blood pressure variability. Blood Press. 2016; 25(1):58-62.
- Zhou D, Xi B, Zhao M, Wang L, Veeranki SP. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study. Sci Rep. 2018; 8(1):9418.
|
| Publication of the article |
«World of Medicine and Biology» №1(71), 2020 year, 013-018 pages, index UDK 616.12-008.331.1-053.81-005-073.432.19-085 |
| DOI |
10.26724/2079-8334-2020-1-71-13-18 |
