Volosovets A.O., Zozulya I.S., Volosovets O.P., Savchenko D.S., Kramareva O.G.

INFLUENCE OF EXCESSIVE NIGHTTIME ACTIVITY ON THE RISK OF ISCHEMIC CEREBRAL STROKE EVENT AND ITS COURSE FEATURES

---

About the author:	Volosovets A.O., Zozulya I.S., Volosovets O.P., Savchenko D.S., Kramareva O.G.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	Clinical neurological and neuroimaging examination of 300 patients with ischemic stroke was performed. The control group included 40 patients without signs of acute cerebral stroke (men - 21, women - 19) aged 46 to 76 years (mean age being 62.6 ± 10.2 years). The data obtained confirmed that the important role of excessive nighttime activity (ENA) is characteristic of all groups of patients, but 100% correlation is observed in patients with nocturnal strokes. In patients with ENA there are two peaks of blood pressure increase: - 9:00 and 21:00. Patterns of blood pressure disorders at night were as follows: 68.4% (n = 13) - night peaker, 26.3% (n = 5) - non dipper, 5.2% (n = 1) - dipper subtype. Against the background of an optimized stroke prevention program, the incidence of recurrent ischemic strokes was by 2.09 times lower than in the control group within 2 years. The present study results show the importance of ENA for the diagnosis and pathogenesis of acute ischemic stroke.
Tags	stroke, excessive nighttime activity, onset time, stroke risk, prevention
Bibliography	Zozulya I, Zozulya A, Volosovets A. Complications of ischemic stroke: Diagnostics, treatment, prevention and rehabilitation. Psychiatry, Psychotherapy and Clinical Psychology 2017, T. 8, №3:375-381 [in Ukrainian] Mishchenko TS. Epidemiologiya tserebrovaskulyarnykh zabolevaniy i organizatsiya pomoshchi bolnym s mozgovym insultom v Ukraine. Ukr. vísn. psikhonevrolohiyi. 2017; 25(1):22-4. [in Russian] Douma LG, Gumz ML. Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med. 2018;119:108–114. Fodor D. M., Gonganau-Nitu D., Perju-Dumbrava L. “Circadian pattern of ischemic stroke onset,” in Human Vet Med Bioflux, vol. 6, pp. 132–139, 2014. Choi Y. I., Seo I.-K., Kim D.-E. et al., “Same pattern of circadian variation according to the season in the timing of ischemic stroke onset: preliminary report,” Sleep Medicine Research, vol. 6, no. 2, pp. 72–76, 2015. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ. Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation. 2014 Jan 21;129(3):e28-e292. Shanmugam V, Wafi A, Al-Taweel N, Busselberg D. Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease. J Local Global Health Sci. 2013; 2013:3. Wirtz PH,  von Känel R. et al. Psychological Stress, Inflammation, and Coronary Heart Disease. Curr Cardiol Rep. 2017 Sep 20;19(11):111 Yadegarfar G, Shahabi J, Garakyaraghi M, The association of anthropometric indices and cardiac function in healthy adults. ARYA Atheroscler. 2019 Jan;15(1):9-13.
Publication of the article	«World of Medicine and Biology» №1(71), 2020 year, 022-026 pages, index UDK 616-079.3. 616.831-005.6
DOI	10.26724/2079-8334-2020-1-71-22-26