Lytvynets LA., Lytvynets-Golutyak V.E., Chopyak V.V.

ASSESSMENT OF IMMUNOLOGICAL DISORDERS IN THE GENESIS OF BRONCHIAL ASTHMA IN CHILDREN WITH DIFFERENT DEGREES OF THE DISEASE CONTROLLABILITY

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About the author:	Lytvynets LA., Lytvynets-Golutyak V.E., Chopyak V.V.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	It is established that children with bronchial asthma may have pronounced changes in their immunological status, concerning both its cell and humoral components, and to a significant extent they are determined by the disease severity. In the examined patients with bronchial asthma, a limited reserve of phagocytic cells and their phagocytic activity have been established. The maximum inhibition of phagocytosis was observed in patients with uncontrolled bronchial asthma (p <0.05). At the same time, in patients with uncontrolled and partially controlled bronchial asthma, a reduction of their regulatory index was registered, which was caused by the reduction of CD4+ portion and the increase of CD8+ content (p <0.05). Manifestation of a positive highest degree correlation (r=0.79, p<0.05) between the blood serum IL-6 content and the BA course severity in children.
Tags	bronchial asthma, children, immunity
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Publication of the article	«World of Medicine and Biology» №1(71), 2020 year, 078-083 pages, index UDK 613.955+616-08
DOI	10.26724/2079-8334-2020-1-71-78-83