| About the author: |
Samborska I.A., Maievskyi O.Y. Ahafonov K.M., Kovalchuk O.I. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
A detailed electron microscopic study on structural components in the lungs of 1-2 months-old rats under the conditions of hyperhomocysteinemia was performed. Experiments were performed on 64 white nonlinear male rats. Attention is drawn to the presence of large amount of fibrin and erythrocytes in the lumen of the alveoli surrounded by an electron-dense substrate, which is similar to the blood plasma consistency, which is obviously due to the surfactant film thinning in the alveoli and the increase in fluid transduction from the capillaries placed in the interalveolar septum. Specific features of the study were the presence of transudate in the alveolar space containing blood plasma proteins and fibrin fibers, sludge phenomenon, which prevented blood flow and edema of respiratory alveolocytes. In young animals, changes occur in the blood-air barrier. They are associated with endothelial dysfunction, which in turn is due to local endothelial cells desquamation, changes in the structure of the basement membranes, their loosening, as a result of their layered structure disturbance and obturation of the capillaries’ lumen by the blood formed elements. Damage of the endothelial lining integrity leads to permeation of plasma, fibrin and formed elements into the lumen of the alveoli. The process is accompanied by edema of the respiratory epithelium, which is the result of increased vascular permeability and intravascular pressure. |
| Tags |
homocysteine, hyperhomocysteinemia, lungs, alveolocytes, mitochondria |
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| Publication of the article |
«World of Medicine and Biology» №1(71), 2020 year, 214-217 pages, index UDK 616.24:616.153.478.6 |
| DOI |
10.26724/2079-8334-2020-1-71-214-217 |
