EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Bilovol O.M., Kniazkova I.I., Bogun M.V., Kuzminova N.V., Korneichuk V.I., Gavrylyuk A.O.

    EFFICACY OF PHARMACOLOGICAL CORRECTION OF MAGNESIUM DEFICIENCY IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES


    About the author: Bilovol O.M., Kniazkova I.I., Bogun M.V., Kuzminova N.V., Korneichuk V.I., Gavrylyuk A.O.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The purpose of the study was to assess the efficacy of therapy with addition of magnesium orotate (MO) in patients (pts) with AH and type 2 DM with hypomagnesemia. The total of 62 pts with AH and DM with hypomagnesemia were examined. After registration of the baseline data, baseline therapy was prescribed to all pts, 32 of them (group 1) obtained an additional MO for 8 weeks and 28 pts were included in the comparison group. It was found that antihypertensive efficacy had been more significant in group 1. In group 1 showed significant positive changes in lipid and carbohydrate metabolism and along with an improvement in the quality of life. Thus, an addition of MO in the complex therapy of pts with AH and DM with hypomagnesemia increases the efficacy of antihypertensive therapy, positively affects glucometabolic parameters and the quality of life in this category of patients.
    Tags magnesium deficiency, arterial hypertension, type 2 diabetes mellitus, daily blood pressure monitoring, treatment
    Bibliography
    • Eremenko NN, Shikh EV, Serebrova SY, Sizova ZM. Comparative study of the bioavailability of magnesium salts. Drug Metab Pers Ther. 2019; 34(3). pii: /j/dmdi.2019.34.issue–3/dmpt–2019–0004/dmpt–2019–0004.xml. doi: 10.1515/dmpt–2019–0004.
    • Gosmanov AR, Lu JL, Sumida K. Synergistic association of combined glycemic and blood pressure level with risk of complications in US veterans with diabetes. J Hypertens. 2016; 34:907–913.
    • Gromova OA, Torshin IY, Kobalava ZD, Nazarenko AG. Systematic Analysis of the Roles of Trace Elements in the Prevention and Treatment of Chronic Heart Failure. Kardiologiia. 2019; 59(6):26–34. doi: 10.18087/cardio.2019.6.n683.
    • Kostov K. Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling. Int J Mol Sci. 2019; 20(6). pii: E1351. doi: 10.3390/ijms20061351.
    • Severino P, Netti L, Mariani MV, Maraone A, D'Amato A, Scarpati R, Infusino F, Pucci M, Lavalle C, Maestrini V, Mancone M, Fedele F. Prevention of Cardiovascular Disease: Screening forMagnesium Deficiency. Cardiol Res Pract. 2019; 2019:4874921. doi: 10.1155/2019/4874921.
    • Song J, Sheng CS, Huang QF, Li LH, Ma CS, Guo XH, Ji LN, Wang JG. Management of hypertension and diabetes mellitus by cardiovascular and endocrine physicians: a China registry. J Hypertens. 2016; 34:1648–53.
    • Torshin IY, Gromova OA, Kalacheva AG, Oshchepkova EV, Martynov AI. Meta–analysis of clinical trials of cardiovascular effects of magnesium orotate. Ter Arkh. 2015; 87(6):88–97. doi: 10.17116/terarkh201587688–97.
    Publication of the article «World of Medicine and Biology» №2(72), 2020 year, 011-016 pages, index UDK [616.12-008.331.1:616.379-008.64]-085.272.2:546.46
    DOI 10.26724/2079-8334-2020-2-72-11-16