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    Ivanov V.P., Kolesnyk M.O., Kolesnуk O.M., Bilonko O.F., Nіushko T.Y.

    CHANGES IN EFFORT TOLERANCE INDICES IN PATIENTS WITH CHRONIC HEART FAILURE AND LATENT IRON DEFICIENCY ON THE BACKGROUND OF THE ORAL FERROTHERAPY


    About the author: Ivanov V.P., Kolesnyk M.O., Kolesnуk O.M., Bilonko O.F., Nіushko T.Y.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation It is known that iron deficiency (ID) in the case of chronic heart failure (CHF), regardless of the presence of anemia, contributes to the development of the skeletal muscle dysfunction, which results in a reduction of effort tolerance (ET) in patients. The objective of the study was to assess the changes in effort tolerance indices in patients with chronic heart failure, with reduced left ventricular ejection fraction and concomitant latent iron deficiency, on the background of a standard treatment combined with long-term oral ferrotherapy. The data obtained showed that the conducted additional oral ferrotherapy is accompanied by a substantial improvement in effort tolerance indices in patients with CHF as compared to the standard therapy alone. This demonstrates the feasibility of a latent ID 6-month oral ferrocorrection to treat CHF with reduced LV EF in order to improve the patients’ condition and working capacity.
    Tags chronic heart failure, latent iron deficiency, oral ferrotherapy
    Bibliography
    • Amosova KM, Tsaralunha VM, Sydorova MM. Viddaleni klinikolaboratorni naslidky medykamentoznoyi korektsiyi zalizodefitsytu u khvorykh na koronarohennu khronichnu sertsevu nedostatnist iz suputnoiu anemiieiu bez yavnykh prychyn vtraty zaliza ta yiyi vplyv na funktsionalnyi stan khvorykh. Sertse i sudyny. 2013; 1(41): 101-9. [in Ukrainian]
    • Ivanov VP, Kolesnyk MO, Kolesnyk OM, Ivanova YeI. Anemii v rakursi problemy khronichnoi sertsevoi nedostatnosti: patohenez i laboratorna diahnostyka. Lvivskyi medychnyi chasopys. 2018; 2 (24): 69-76. [in Ukrainian]
    • Mozhina TL. Zhelezodefitsit v praktike semeynogo vracha. Zdorovya Ukrayiny XXІ storіchcha. 2017; 24: 44-45. [in Russian]
    • Voronkov L.G. Anemiya u patsiyenta z KhSN: yak otsiniuvaty ta likuvaty? Sertseva nedostatnist. 2015; 2: 5-13. [in Ukrainian]
    • Voronkov LG, Lutsak OO, Babych PM, Liashenko AV. Predyktory yakosti zhyttia u khvorykh iz khronichnoyu sertsevoyu nedostatnistyu. Ukrainskyi medychnyi chasopys. 2011; 3: 86-88. [in Ukrainian]
    • Vydyborets SV. Optymalnyi vybir ionnykh i neionnykh preparativ zaliza pry likuvanni zalizodefitsytnoyi anemiyi u vahitnykh (pohliad na problemu). Zdorovye zhenshchynu. 2015; 8: 34-41. [in Ukrainian]
    • Anker SD, Kirwan BA, van Veldhuisen DJ, Filippatos G, Comin-Colet J, Ruschitzka F, et al. Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis. Eur J Heart Fail. 2018; 20: 125-33.
    • Comin-Colet J, Enjuanes C, Gonzalez G, Torrens A, Cladellas M, Merono O, et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Europ. J. of Heart Failure. 2013; 15: 1164-72.
    • Cunha GJL, Rocha BML, Menezes Falcão L. Iron deficiency in chronic and acute heart failure: A contemporary review on intertwined conditions. Eur J Intern Med. 2018; 52: 1-7.
    • Duygu K, Kadri MG. Iron deficiency and its treatment in heart failure: indications and effect on prognosis. E-Journal of Cardiology Practice. 2016; Available from: https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-14/Iron-deficiency-and-its-treatment-in-heart-failure-indications-and-effect-on-prognosis.
    • Dziegala M, Josiak K, Kasztura M, von Haehling S, Banasiak W, Anker SD, et al. Iron deficiency as energetic insult to skeletal muscle in chronic diseases. J Cachexia Sarcopenia Muscle. 2018; 9(5): 802–815.
    • Jankovska E, von Haeling S, Anker S, Macdougall I, Ponikowski P. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Europ. Heart J. 2013; 34: 816-26.
    • Klip I, Comin-Colet J, Voors A. Iron deficiency in chronic heart failure: an international pooled analysis. Am. Heart J. 2013; 165: 575-82.
    • Mamas M, Sperrin M, Watson M. Do patients have worse outcomes in heart failure than in cancer? A primary carebased cohort study with 10-year follow-up in Scotland. Eur. J. Heart Fail. 2017; 19: 1095-1104.
    • Pocock SJ, Ariti CA, McMurray JV. Predicting survival in heart failure: a risk score based on 39372 patients from 30 studies. Eur. Heart J. 2013; 34: 1404-13.
    Publication of the article «World of Medicine and Biology» №2(72), 2020 year, 058-063 pages, index UDK 616.12-008.46:616.155.194-085:796.015
    DOI 10.26724/2079-8334-2020-2-72-58-63