English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Shkurupii D.A., Mogylnyk A.I., Sonnik E.G., Udovytska N.O.

    STATE OF GASTROINTESTINAL MUCOSAL PROTECTION IN NEUROLOGICAL PATIENTS IN CRICICAL STATE


    About the author: Shkurupii D.A., Mogylnyk A.I., Sonnik E.G., Udovytska N.O.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation An observational clinical study was performed with 50 adult participants. The main group consisted of 30 patients with cerebrovascular diseases of the cerebrovascular diseases, which required the organization of intensive care. In the main group, on the 1st day of observation, the level of glycosaminoglycans was higher in 70% (21/30) cases. On the 7th day of observation, this indicator was higher in 100% (30/30) cases. Correlations between the increase in the concentration of glycosaminoglycans and their age, the severity of the condition in accordance with APACHE II, and the start time of enteral nutrition were established. Thus, in neurological patients in critical condition, the protection system of the gastrointestinal mucosa is in a state of functional tension.
    Tags glycosaminoglycans, gastrointestinal tract, vascular syndromes of brain in cerebrovascular diseases, intensive care
    Bibliography
    • Milyukov VE, Dolgov EN, Nguen KK, Polunin SV. Faktory agressii i zashchity slizistoy obolochki zheludka pri ostroy tonkokishechnoy neprokhodimosti. Vestnik eksperimentalnoy i klinicheskoy khirurgii. 2012; 5(3): 596-600. [in Russian]
    • Nikonov VV, Kursov SV, Yakovtsov IZ, Zagurovskiy VM, Chernov AL, Savitskaya IB, et al. Problemy nedifferentsirovannoy terapii u bolnykh s sindromom ostroy tserebralnoy nedostatochnosti (analiticheskiy obzor). Chast 1 /. Meditsina neotlozhnykh sostoyaniy. 2016; 1(72): 30-8. [in Russian]
    • Petry A., Sebyn K, editors. Nagliadnaya meditsinskaya statistika: ucheb. posobiye. Moskva: HEOTAR-Medya; 2015. 216 s. [in Russian]
    • Teriv PS, Shkurupii DA. Tsynk-zalezhni vplyvy pry intensyvnii terapii u khvorykh z nevrolohichnoiu patolohiieiu. Visnyk problem biolohii i medytsyny. 2014; 2: 3 (109): 48-52. [in Ukrainian]
    • Buendgens L, Koch A, Tacke F. Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World J Crit Care Med. 2016 Feb 4;5(1):57-64. doi: 10.5492/wjccm.v5.i1.57.
    • Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015; 28(2):203–209.
    • García B, Merayo-Lloves J, Martin C, Alcalde I, Quirós LM, Vazquez F. Surface proteoglycans as mediators in bacterial pathogens infections. Front Microbiol. 2016 Feb 24; 7:220. doi: 10.3389/fmicb.2016.00220.
    • Hakansson AP, Orihuela CJ, Bogaert D. Bacterial-host interactions: physiology and pathophysiology of respiratory infection. Physiol Rev. 2018 Apr 1; 98(2):781-811. doi: 10.1152/physrev.00040.2016.
    • Haussner F, Chakraborty S, Halbgebauer R, Huber-Lang M. Challenge to the intestinal mucosa during sepsis. Front Immunol. 2019 Apr 30; 10:891. doi:10.3389/fimmu.2019.00891.
    • Kawai K, Kamochi R, Oiki S, Murata K, Hashimoto W. Probiotics in human gut microbiota can degrade host glycosaminoglycans. Sci Rep. 2018 Jul 13; 8(1):10674. doi: 10.1038/s41598-018-28886-w.
    • Lerner A, Neidhöfer S, Matthias T. The gut microbiome feelings of the brain: A perspective for non-microbiologists. Microorganisms. 2017; 5(4):66. doi: 10.3390/microorganisms5040066
    • Lew CCH, Wong GJY, Cheung KP. The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity. Crit Care. 2019; 23(1):222. Published 2019 Jun 18. doi:10.1186/s13054-019-2500-z
    • Miller I. The gut-brain axis: historical reflections. Microb Ecol Health Dis. 2018 Nov 8; 29(1):1542921. doi: 10.1080/16512235.2018.1542921.
    • Nadatani Y, Watanabe T, Shimada S, Otani K, Tanigawa T, Fujiwara Y. Microbiome and intestinal ischemia/reperfusion injury. J Clin Biochem Nutr. 2018 Jul; 63(1):26-32. doi: 10.3164/jcbn.17-137.
    • Shmagel A, Demmer R, Knights D, Butler M, Langsetmo L, Lane NE, et al. The Effects of glucosamine and chondroitin sulfate on gut microbial composition: a systematic review of evidence from animal and human studies. Nutrients. 2019 Jan 30; 11(2). pii: E294. doi: 10.3390/nu11020294.
    Publication of the article «World of Medicine and Biology» №2(72), 2020 year, 138-141 pages, index UDK 616.8+3
    DOI 10.26724/2079-8334-2020-2-72-138-141