| About the author: |
Kuzmenko Y.Y., Stechenko L.O., Chuhrai S.M., Kozak H.I., Oliinyk T.M. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Blood capillaries of rat renal glomeruli were studied 14, 50 and 100 days after the development of congenital hypothyroidism. It was found that on day 14 after the onset of hypothyroidism 7-day-old rats had a decrease in morphometric parameters of the number of capillaries and their area in comparison with age control in the absence of any marked morphological changes. In 45-day-old rats 50 days after the development of this pathology in glomerular blood capillaries changes in quantitative indicators had not reached critical values, while the presence of both destructive-dystrophic and compensatory processes were noted morphologically. 100 days after the development of pathology changes in blood capillaries became more pronounced than in the previous period. Destructive-dystrophic changes of a part of capillaries and the phenomena of necrosis and apoptosis were observed in the presence of compensatory-adaptive processes. |
| Tags |
blood capillaries, kidneys, rats, congenital hypothyroidism |
| Bibliography |
- Dzugkoev ST, Mozhayeva IV, Tokayeva EA. Mekhanizmy razvitiya endotelialnoy disfunktsii i perspektivy korrektsii.Fundamentalnye issledovaniya. 2014, 4(1): 198-199. [in Russian]
- Zelinska NB, Larin AS. Patologiya shitopodibnoyi zalozy u dityachoho naselennya Ukrayiny. Klinichna endokrinolohiya ta endokrynna khirurhiya. 2016; 3: 76-80. [in Ukrainian]
- Kuzmenko YuYu, Koveshnikov VG. Dinamika organometrychnykh pokaznykiv nyrok shchuriv v umovakh vrodzhenoho hipotyreozu. Ukrayinskyi medychnyi almanakh. 2012; 15 (5):179-181.
- Mamenko ME. Hipotyreoz u ditey. Dityachyi likar. 2013; 3(24):32-39.
- Orlova MM. Vikovi osoblyvosti funktsiyi nyrok u patsiyentiv z manifestnym hipotyreozom. Fundamentalni doslidzhennya. 2012; 4:347-351.
- Chuhray S.M. Ultrastruktura krovonosnykh kapilyariv miokarda statevozrilikh shchuriv iz vrodzhenymhipotyreozom. Svit medytsyny ta biolohiyi. 2010; 4: 164 – 168.
- Basu G, Mohapatra A. Interaction between thyroid disordes and kidney disease. Indian J Endocrinol Metab. 2012 Mar; 16(2):204-213.
- Iglesias P, Bajo MA, Selgas R, Díez JJ. Thyroid dysfunction and kidney disease: An update. Rev Endocr Metab Disord. 2017 Mar; 18(1):131-144.
- Kriz W. Fenestrated Glomerular Capillaries Are Unique. J Am Soc Nephrol. 2008; 19: 1439-1440.
- Kroemer G, Galluzzi L, Vandenabeele Р. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. 2009. Cell Death. Differ. 2009; 16(1): 3.
- Sorribas V, Lötscher М, Loffing J, Biber J. Cellular mechanisms of the age-related decrease in renal phosphate reabsorption. Kidney Int.1996; 50(3): 855 - 63.
- Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015;. 3(4):286—95.
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| Publication of the article |
«World of Medicine and Biology» №2(72), 2020 year, 170-174 pages, index UDK 611.611:611.161:57.012.4:616.441-008.64-053.1 |
| DOI |
10.26724/2079-8334-2020-2-72-170-174 |
