| About the author: |
Lykhatskyi P.H., Fira L.S., Ivanusa I.B., Fira D.B. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Intoxication rats of tobacco smoke was simulated in sealed chamber by burning 6 cigarettes (within 45 days). 24 and 72 hours before the end of the experiment, animals were injected with sodium nitrite at the dose of 45 mg/kg body weight, enterosorbent Carboline at the dose of 400 mg/kg (within 30 days). Increase in the content of met- and carboxyhemoglobin in rats’ blood of all age groups during the experiment was noted. Immature rats were the most sensitive to simultaneous toxicant damage. The blood serum of affected old rats showed the highest content of C-reactive protein (3.3 times higher than the normal). Carboline had most effect on this index at the end of the study. In blood serum of affected rats in all age groups, shift in the cytokine balance towards pro-inflammatory processes was observed (increase in the content of interleukin-6 and decrease in interleukin-4). Enterosorbent had the most effect on the cytokine balance in mature rats. |
| Tags |
nitrite-tobacco intoxication, meth- and carboxyhemoglobin, cytokines, C-reactive protein |
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| Publication of the article |
«World of Medicine and Biology» №2(72), 2020 year, 180-185 pages, index UDK 616-003.96+616-002:613.84+615.9-085]-092.4 |
| DOI |
10.26724/2079-8334-2020-2-72-180-185 |
