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    Maslova G.S., Skrypnyk R.I., Gopko O.F., Skrypnyk I.M.

    THE ROLE OF ARGININE/CITRULLINE CYCLE DISORDERS IN THE PATHOGENESIS OF DOXORUBICIN-INDUCED LIVER INJURY ASSOCIATED WITH NONALCOHOLIC STEATOHEPATITIS IN RATS


    About the author: Maslova G.S., Skrypnyk R.I., Gopko O.F., Skrypnyk I.M.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The article presents the results of an experimental study aimed to investigate the features of arginine / citrulline cycle disorders associated with doxorubicin-induced liver injury in rats, concomitant with NASH. The study involved adult fertile outbred albino rats (n=30; male rats=15 (50%); female rats=15 (50%)) weighted 160-220 g. The rats were assigned into 3 groups: Group І (n=10) involved rats with NASH, administered with intraperitoneal 5 mg/kg doxorubicin for 3 days; Group ІІ (n=10) involved rats without NASH, administered with intraperitoneal doxorubicin similar to Group I regimen; Group ІІІ (n=10) – control group. It has been shown that administration of doxorubicin in rats with NASH leads to disorders of arginine/citrulline cycle, which are characterized by inhibition of arginase activity and activation of citrulline synthesis.
    Tags arginine, citrulline, arginase, doxorubicin, hepatotoxic reactions, nonalcoholic steatohepatitis
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    Publication of the article «World of Medicine and Biology» №2(72), 2020 year, 188-192 pages, index UDK 616.36-0,02:611.018:599.323.4
    DOI 10.26724/2079-8334-2020-2-72-188-192