Polishchuk S.S., Skyba V.Ya., Davydenko I.S., Shuvalov S.M., Gavrilyuk A.O., Yakovtsova І.І., Polishchuk В.С.

HISTOLOGICAL CHANGES OF BONE TISSUE IN THE PERFORATION DEFECT SITE OF THE RAT MANDIBLE WHEN USING HEPATOPROTECTOR IN ODSTRUCTIVE HEPATITIS

---

About the author:	Polishchuk S.S., Skyba V.Ya., Davydenko I.S., Shuvalov S.M., Gavrilyuk A.O., Yakovtsova І.І., Polishchuk В.С.
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	The purpose of the study was to experimentally investigate the features of reparative regeneration of the mandibular defect in rats with obstructive hepatitis against the background of hepatoprotector administration. An experimental study was performed on 60 white male Wistar rats, weighing 240-270 g. In the process of work, the rats were divided into 3 groups (20 rats in each one): control - included healthy rats with mandibular trauma; experimental group 1 - rats with jaw injury and simulated obstructive hepatitis; experimental group 2 - rats with mandibular injury + obstructive hepatitis + complex hepatoprotector. The experiment revealed that obstructive hepatitis impairs bone tissue healing in the site after the traumatic defect. The use of hepatoprotector, in experimental obstructive hepatitis, is a very effective measure for the processes of bone regeneration at the site of perforation.
Tags	experiment, rats, mandibular injury, obstructive hepatitis, hepatoprotector
Bibliography	Malanchuk VO, Lohvinenko IP, Malanchuk TO. Khirurhichna stomatolohiya ta shchelepno-lytseva khirurhiya: pidruchnyk.. Kyiv: LOHOS, 2011. 606 c. [in Ukrainian] Moroz LV, Musayev EEO, ZaichkoNV, Androsova OS, Hayduk OA. Vplyv vitaminu D na rezultaty likuvannya khronichnoho hepatytu С. Hepatolohiya. 2016; 4:42-50. [in Ukrainian] Tymofeyev OO. Shchelepno-lytseva khirurhiya. Kyiv: VSV “Medytsyna”, 2011. 752 s. [in Ukrainian] Gutta R, Tracy K, Johnson C. Outcomes of mandible fracture treatment at an academic tertiary hospital: a 5-year analysis. J. Oral Maxillofac. Surg. 2014; 72; 3: 550–558. Moroz LV, Bondaruk IYu, Popovich AA. Comparison of the diagnostic efficiency of various noninvasive methods for diagnosing liver fibrosis in patients with chronicviral hepatitis C. Journal of Education, Healthand Sport. 2019; 9(6): 546-555. Polischuk SS, Davydenko IS, Shuvalov SM. Effect of the Forcalon histological changes of the rat’s mandible bonet issue in the area of the traumatic defect at the pathology of the hepatobiliary system. Вісник морфології. 2018; 1(24): 47-55.
Publication of the article	«World of Medicine and Biology» №2(72), 2020 year, 193-198 pages, index UDK 616-001.52:616.01/09:616-06:619
DOI	10.26724/2079-8334-2020-2-72-193-198