About the author: |
Bezshapochniy S.B., Loburets V.V., Loburets A.V., Dzhirov O.R., Podovzhniy O.G. |
Heading |
CLINICAL MEDICINE |
Type of article |
Scentific article |
Annotation |
The article describes the problems of choosing a solution for the nasal cavity irrigation in acute viral rhinosinusitis. The purpose of the study was to establish the effectiveness of restoring the physiological function of nasal structures by adding to the traditional (3% NaCl solution) saline solution, 6% N-acetylcysteine solution in combination with classical treatment regimen of acute rhinosinusitis. It was found that this combination can effectively restore the mucociliary transport of the nasal mucosa and thus reduce the risk of complications or the migration of the disease into a bacterial form. As a result of the study, we concluded that the combination of N-acetylcysteine with saline solution in the treatment of acute viral rhinosinusitis and improving both the objective and subjective condition of patients. |
Tags |
acute viral rhinosinusitis, irrigation, N-acetylcysteine, saline solutions |
Bibliography |
- Bezshapochnyi SB, Podovzhniy OH, Hryshyna IS., Suchasni aspekty likuvannya khvorykh na hostri rynosynusyty z obtyazhenym alerholohichnym anamnezom. Zhurnal vushnykh, nosovykh i horlovykh khvorob. 2017; 3:13. [in Ukrainian]
- Kunelskaya NL. Osnovnyye komponenty nazalnogo sekreta. Mukoaktivnyye sredstva vo vrachebnoy praktike. Lechebnoye delo. 2013; 3:4–7. [in Russian]
- Aldini G., Altomare A., Baron G., Vistoli G., Carini, M., et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 2018; 52(7):751–62.
- Aslam S, Darouiche RO. Role of Antibiofilm-Antimicrobial Agents in Controlling Device-Related Infections. The International Journal of Artificial Organs. 2011; 34(9):752–58.
- Bahtouee M, Monavarsadegh G, Ahmadipour M, Motieilangroodi M, Motamed N, et al. Acetylcysteine in the treatment of subacute sinusitis: A double-blind placebo-controlled clinical trial. Ear, nose, and throat journal. 2017; 96(1):7-11.
- Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R., Reitsma S., et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020: 29:1-464.
- Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP. Psychometric validity of the 22-item Sinonasal Outcome Test. Clin Otolaryngol. 2009; 34(5):447-54.
- Macchi A, Terranova P, Castelnuovo P. Recurrent acute rhinosinusitis: a single blind clinical study of N-acetylcysteine vs ambroxol associated to corticosteroid therapy. International journal of immunopathology and pharmacology. 2012; 25(1):207-17.
- Salati H, Bartley J, White DE. Nasal saline irrigation. A review of current anatomical, clinical and computational modelling approaches. Respire Physiologic Neurobiology. 2020; 1:273.
- Succar EF, Turner JH, Chandra RK. Nasal saline irrigation: a clinical update. International forum of allergy and rhinology.2019; 9(1): 4-8.
- The mucosal immune system of the respiratory tract. Current Opinion in Virology. 2012; 2(3):225-232.
- Zhao T, Liu, Y. N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa. BMC Microbiology. 2010; 10(1):140.
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Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 007-012 pages, index UDK 616.2+616-08+616-03 |
DOI |
10.26724/2079-8334-2020-3-73-7-12 |