| About the author: |
Kyrian O.A., Dorofeyev A.E., Khaymenova G.S., Dorofeyeva A.A. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the work was to study the features of the IL1 (T-31C), IL1 (T-511C), IL6 (C-174 G), IL10 (592C> A), IL10 (C-819T), IL10 (G- 1082A), Tlr2 (Thr399ile), Tlr4 (Thr399ile), Tlr4 (Asp299Gly) genes polymorphic variants influence on the development of ulcerative colitis in patients. The total of 53 patients with ulcerative colitis were examined, the control group included a random sample of 49 healthy persons. Association of the ulcerative colitis development with the incidence of single nucleotide polymorphism of IL10 wild genotype gene (rs1800896), homozygous G/G genotype of single nucleotide polymorphism of the Tlr4 gene (rs4986790), the frequency of the T allele in the IL1 gene (rs1143627), C allele in the IL1 gene (rs 16944) and IL10 (rs1800872), which contributed to the disturbance and imbalance in the production of pleiotropic cytokines IL1 and IL10, predisposing to the development of ulcerative colitis and aggravating the course of the disease. The work shows associative links for single nucleotide polymorphism of Tlr4 gene (rs4986791) with the development of nonspecific ulcerative colitis both according to the multiplicative model with the C allele and according to the general inheritance model with the wild type of C/C genotype, which confirms the importance of this single nucleotide polymorphism in the development of the disease. |
| Tags |
nonspecific ulcerative colitis, single nucleotide gene polymorphism, allele, genotype |
| Bibliography |
- Dorofeyev AE, Kyrian ЕA. Nekotorye geneticheskie prediktory razvitiya patologii kishechnika. Svit medytsyny ta biolohiyi. 2014; 4(47): С.31-34. [in Russian]
- Kushnyr IE. Terapevticheskie strategii lecheniya yazvennogo kolita: realii i perspektivy. Suchasna hastroenterolohiya. 2016; 4(90):108 – 15. [in Russian]
- Stavtsev DS, Astrelyna TA, Kniazev OV, Pukhlykova TV. Znachenie immunogeneticheskikh faktorov v razvitii bolezni Krona. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2015; 25(3):70–77. [in Russian]
- Svystunov AA, Osadchuk MA. Bolezni kishechnika. Moskva: Laboratoriya znanij; 2016. 277 s. [in Russian]
- Abraham C, Cho J.Interleukin-23/Th17 Pathways and Inflammatory Bowel Disease. Inflamm Bowel Dis. 2009; Feb 15(7): 1090–100. DOI: 10.1002/ibd.20894.
- Cario E. Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis. 2010; Sep16(9):1583—97.DOI: 10.1002/ibd.21282.
- Cheng Y, Zhu Y, Huang X, Zhanq W, Han Z, Liu S. Association between TLR2and TLR4 gene polymorphisms and the susceptibility to inflammatory bowel disease: A meta-analysis. PLoS One. 2015; May 10 (5): e0126803. DOI: 10.1371/journal.pone.0126803.
- Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, et al. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.The Lancet.2016; Jan 9;387(10014): 156-67. DOI: 10.1016/S0140-6736(15)00465-1.
- Fareed M, Afzal M. Single nucleotide polymorphism in genome-wide association of human population: A tool for broad spectrum service. Egyptian Journal of Medical Human Genetics. 2013; 14(2): 123-34. DOI: 10.1016/ j.ejmhg.2012.08.001.
- Fonseca-Camarillo G, Yamamoto-Furusho JK. Immunoregulatory pathways involved in inflammatory bowel disease. Inflamm Bowel Dis.Sep 2015; 21 (9): 2188 — 93. DOI: 10.1097/MIB.0000000000000477.
- Visscher PM, Wray NR, Zhag Q, Sklar P, McCathy MI, Brown MA, Yang J. 10 Years of GWAS Discovery: Biology, Function, and Translation. AJHG. 2017; 101(1): 5–22. DOI:10.1016/j.ajhg.2017.06.005.
- Zhu H, Lei X, Liu Q, Wang Y. Interleukin-10 — 1082A/G polymorphism and inflammatory bowel disease susceptibility: a meta-analysis based on 17,585 subjects. Cytokine. 2013; Jan 61 (1): 146 — 53. DOI: 10.1016/j.cyto.2012.09.009.
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| Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 052-056 pages, index UDK 616.34 – 002: 575+591.151 |
| DOI |
10.26724/2079-8334-2020-3-73-52-56 |
