| About the author: |
Pypa L.V., Svistilnik R.V., Romanchuk K.Yu., Gordiichuk О.О., Smolko D.G. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
We analyzed 123 cases of аcute bacterial meningitis, where 74 cases were in men and 49 cases - in women. 93.5% of cases began with fever, headache (86.2%), vomiting (69.9%), epileptic seizures (1.6%), altered level of consciousness (17.8%) and meningeal syndrome (80,2%). The etiological factor was established in 20.3% of patients. In 41.4% of patients neurological complications were observed. The terminal end was observed in 7.3% of patients. The main causative agent of аcute bacterial meningitis was S. pneumoniae (56.0%), the second place was taken by N. meningitidis (36.0%), the third one was divided between S. aureus and L. monocytogenes (4.0%). Brain edema (90.2%), paresis of extremities (11.7%) and epileptic seizures (7.8%) were frequent complications. The prevalence of аcute bacterial meningitis was 0.86 per 100 thousand population per year in the ratio between men and women of 1.5:1 and the total annual mortality of 0.06 per 100 thousand population. |
| Tags |
bacterial meningitis, epidemiology, etiology, adults |
| Bibliography |
- Bodilsen J, Dalager-Pedersen M, Schønheyder HC, Nielsen H. Stroke in community-acquired bacterial meningitis: a Danish population-based study. Int J Infect Dis 2014; 20: 18–22.
- Braun J S, Hoffmann O, Schickhaus M, Freyer D, Dagand E, Bermpohl D, Mitchell T J, Bechmann I, Weber J R. Pneumolysin causes neuronal cell death through mitochondrial damage. Infection and Immunity. 2007; 75(9): 4245–4254.
- Brouwer M C, Tunkel A R, van de Beek D. Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis. Clinical Microbiology Reviews. 2010; 23(3): 467-92.
- Castelblanco R L, Lee M, Hasbun R. Epidemiology of bacterial meningitis in the USA from 1997 to 2010: a population-based observational study. Lancet Infect Dis. 2014; 14(9): 813–819.
- Domingo P, Pomar V, de Benito N, Coll P. The spectrum of acute bacterial meningitis in elderly patients. BMC Infectious Diseases. 2013; 13: 108.
- Heydari B, Khalili H, Karimzadeh I, Emadi-Kochak H. Clinical, Paraclinical, and Antimicrobial Resistance Features of Community-Acquired Acute Bacterial Meningitis at a Large Infectious Diseases Ward in Tehran, Iran. Iranian Journal of Pharmaceutical Research. 2016; 15 (1): 347-354.
- Julayanont P, Ruthirago D, De Toledo JC. Bacterial meningitis and neurological complications in adults. The Southwest Respiratory and Critical Care Chronicles. 2016; 4(14): 5-16.
- Khan F Y, Abu-Khattab M, Almaslamani E A, Hassan A A, Mohamed S F, Elbuzdi A A, Elmaki N Y, Anand D, Sanjay D. Acute Bacterial Meningitis in Qatar: A Hospital-Based Study from 2009 to 2013. BioMed Research International 2017; 2017: 2975610.
- Klein M, Koedel U, Pfefferkorn T, Zeller G, Woehrl B, Pfister H-W. Arterial cerebrovascular complications in 94 adults with acute bacterial meningitis. Critical Care. 2011; 15: 281.
- Koroleva I S, Beloshitsky G V, Koroleva M A, Zakroyeva I M, Spirikhina L V, Mironov K O, Shipulin G A. Meningococcal infection and purulent bacterial meningitis in the Russian Federation: 10-year epidemiological observation. Epidemiology and Infectious Diseases. 2013; 2: 15-20.
- Lai W-A, Chen S-F, Tsai N-W, Chang C-C, Chang W-N, Lu C-H, Chuang Y-C, Chien C-C, Huang C-R. Clinical characteristics and prognosis of acute bacterial meningitis in elderly patients over 65: a hospital-based study. BMC Geriatrics. 2011; 11: 91.
- Manjiyil I J, Moorkoth A P, Santhakumari R D. Bacteriological profile of acute bacterial meningitis in adults in a tertiary care hospital in North Kerala. J. Evolution Med. Dent. Sci. 2016; 5(46): 2884-2888.
- McGill F, Heyderman R S, Panagiotou S, Tunkel A R, Solomon T. Acute bacterial meningitis in adults. The Lancet. 2016; 388(10063): 3036-3047.
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| Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 081-087 pages, index UDK 616.831-002 |
| DOI |
10.26724/2079-8334-2020-3-73-81-87 |
