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    Antonenko P.P., Zazharskyi V.V., Suslova N.I., Sklyarov P. M., Reshetnichenko O.P., Kostyuk V.K., Mylostyvyi R.V.


    About the author: Antonenko P.P., Zazharskyi V.V., Suslova N.I., Sklyarov P. M., Reshetnichenko O.P., Kostyuk V.K., Mylostyvyi R.V.
    Type of article Scentific article
    Annotation In this paper, the efficacy of essential oils in the composition of Fitohol herbal medicinal product against the background of tetrachloromethane induced toxic hepatitis in laboratory rats has been studied. It was established that the injection of Fitohol in rats at the dose of 0.03 g per 100 g of body weight positively influenced the clinical condition of animals, facilitated the manifestation of hepatocellular failure and the development of destructive changes in hepatocytes (reducing the activity of alkaline phosphatase, alanine and aspartate aminotransferases in blood plasma and oxyproline, hexosamines and malonic dialdehyde in liver homogenates) in acute toxic hepatitis. In the long-term intoxication of rats with CCl4, the effect of Fitohol was manifested in improving the functional state of the hepatobiliary system and some restoration of the protein- synthesizing liver function.
    Tags herbal medicinal product, tetrachloromethane induced toxic hepatitis, blood plasma, liver homogenate, white rats
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    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 149-154 pages, index UDK 615.322:582.751:615.273
    DOI 10.26724/2079-8334-2020-3-73-149-154