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    Maslova G.S., Skrypnyk I.M., Yeroshenko G.A.

    MORPHOLOGICAL FEATURES OF DOXORUBICIN-INDUCED LIVER DAMAGE ASSOCIATED WITH NONALCOHOLIC STEATOHEPATITIS


    About the author: Maslova G.S., Skrypnyk I.M., Yeroshenko G.A.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The paper consideres the study of histological features of anthracycline-induced liver lesions concomitant with non-alcoholic steatohepatitis.The findings of the study have established the presence of moderate fatty degeneration of the liver with mild focal protein dystrophy of hepatocytes in the lobules of the animals with experimental non-alcoholic steatohepatitis. In the group of animals with anthracycline-induced liver damage, moderate periportal necrosis of hepatocytes along with a mild small-droplet fatty degeneration. Prominent total (centrilobular and periportal) subacute liver necrosis along with moderate fatty degeneration was found in animals with anthracycline-induced liver damage associated with experimental non-alcoholic steatohepatitis.
    Tags non-alcoholic steatohepatitis, anthracycline-induced liver damage, rats
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    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 189-194 pages, index UDK 616.36-002
    DOI 10.26724/2079-8334-2020-3-73-189-194