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    Mykytenko A.O., Yeroshenko G.A.

    REACTION OF HEMOMICROCIRCULATORY BED OF RAT LIVER AND CHANGES IN THE FUNCTIONAL STATE OF THE NITRIC OXIDE CYCLE UNDER THE CONDITIONS OF MODELING ALCOHOLIC HEPATITIS


    About the author: Mykytenko A.O., Yeroshenko G.A.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The purpose of the work was to study the changes in the hemomicrocirculatory bed of the liver and the role of the NO-ergic system in their development under the conditions of modeling alcoholic hepatitis. At the early stages of modeling alcoholic hepatitis, the thickness of the vascular wall of the central vein, interlobular artery and lobular arterioles increases, while the thickness of the vascular wall of the interlobular vein, the lobular venule and the sublobular vein decreases. These changes are associated with dysregulatory changes in the nitric oxide cycle in rat liver. Dysregulatory changes are manifested by an increase in the activity of inducible and constitutive isoforms of NO synthases against the background of decreased activity of arginases in the absence of statistically significant changes in the activity of nitrate and nitrite reductases in the liver of rats with simulated alcoholic hepatitis.
    Tags liver, alcoholic hepatitis, nitric oxide cycle, rats
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    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 194-200 pages, index UDK 616.36-002:661.98
    DOI 10.26724/2079-8334-2020-3-73-194-200