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    Mykytenko A.O., Yeroshenko G.A.


    About the author: Mykytenko A.O., Yeroshenko G.A.
    Type of article Scentific article
    Annotation The purpose of the work was to study the changes in the hemomicrocirculatory bed of the liver and the role of the NO-ergic system in their development under the conditions of modeling alcoholic hepatitis. At the early stages of modeling alcoholic hepatitis, the thickness of the vascular wall of the central vein, interlobular artery and lobular arterioles increases, while the thickness of the vascular wall of the interlobular vein, the lobular venule and the sublobular vein decreases. These changes are associated with dysregulatory changes in the nitric oxide cycle in rat liver. Dysregulatory changes are manifested by an increase in the activity of inducible and constitutive isoforms of NO synthases against the background of decreased activity of arginases in the absence of statistically significant changes in the activity of nitrate and nitrite reductases in the liver of rats with simulated alcoholic hepatitis.
    Tags liver, alcoholic hepatitis, nitric oxide cycle, rats
    • Akimov OYe, Kostenko VO. Functioning of nitric oxide cycle in gastric mucosa of rats under excessive combined intake of sodium nitrate and fluoride. Ukr. Biochem. J. 2016; 88 (6): 70-75. doi: https://doi.org/10.15407/ubj88.06.070
    • De Oliveira GA, Cheng RYS, Ridnour LA, Basudhar D, Somasundaram V, McVicar DW, Monteiro HP, Wink DA. Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers. Antioxid Redox Signal. 2017 Jun 20; 26(18):1059-1077. doi: 10.1089/ars.2016.6850.
    • Dou L, Shi X, He X, Gao Y. Macrophage Phenotype and Function in Liver Disorder. Front Immunol. 2020 Jan 28; 10:3112. doi: 10.3389/fimmu.2019.03112.
    • Florentino IF, Silva DPB, Silva DM, Cardoso CS, Moreira ALE, Borges CL, Soares CMA, Galdino PM, Lião LM, Ghedini PC, Menegatti R, Costa EA. Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: The role of nitric oxide. Nitric Oxide. 2017 Sep 30; 69:35-44. doi: 10.1016/j.niox.2017.04.006.
    • Fuster D, Samet JH. Alcohol Use in Patients with Chronic Liver Disease. N Engl J Med. 2018 Sep 27; 379(13):1251-1261. doi: 10.1056/NEJMra1715733.
    • Khambu B, Wang L, Zhang H, Yin XM. The Activation and Function of Autophagy in Alcoholic Liver Disease. Curr Mol Pharmacol. 2017; 10(3):165-171. doi: 10.2174/1874467208666150817112654.
    • Koop DR, Klopfenstein B, Iimuro Y, Thurman RG. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol. 1997 Jun; 51(6):944-50. doi: 10.1124/mol.51.6.944.
    • Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G. Alcoholic disease: liver and beyond. World J Gastroenterol. 2014 Oct 28; 20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652.
    • Saikia P, Bellos D, McMullen MR, Pollard KA, de la Motte C, Nagy LE. MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol. Hepatology. 2017 Aug; 66(2):602-615. doi: 10.1002/hep.29144.
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014 May; 146(6):1513-24. doi: 10.1053/j.gastro.2014.01.020.
    • Stepanov Yu.M., Didenko V.I., Dynnik O.B., Konenko I.S., Oshmianskaia N.Yu., Galinsky A.A. Association of morphological changes in the liver parenchyma and its rigidity under the conditions of the experimental modeling of alcoholic and toxic hepatitis. Journal of the NAMSU. 2017; 23 (3-4): 196-204.
    • Yelinska AM, Akimov OYe, Kostenko VO. Role of AP-1 transcriptional factor in development of oxidative and nitrosative stress in periodontal tissues during systemic inflammatory response. Ukr.Biochem. J. 2019; 9: 80-85. doi: https://doi.org/10.15407/ubj91.01.080.
    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 194-200 pages, index UDK 616.36-002:661.98
    DOI 10.26724/2079-8334-2020-3-73-194-200