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    Seredynska N.M., Korniyenko V.I., Marchenko-Tolsta K.S., Bobrytska O.M., Ladohubets O.V., Duchenko K.A.

    CARDIOTROPIC INFLUENCE OF SYNTHETIC AND GENETICALLY-ENGINEERED SUPPRESSORS IN RATS WITH EXPERIMENTAL RHEUMATOID ARTHRITIS COMBINED WITH ARTERIAL HYPERTENSION


    About the author: Seredynska N.M., Korniyenko V.I., Marchenko-Tolsta K.S., Bobrytska O.M., Ladohubets O.V., Duchenko K.A.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Significant progress in rheumatoid arthritis pharmacotherapy is associated with the implementation of synthetic–derived immunosuppressors and genetically engineered (biological) drugs) into clinical practice. Arterial hypertension, like rheumatoid arthritis, is accompanied by producing a large amount of inflammatory cytokines, namely TNF–ά. The purpose of the work was to study the cardiotropic effects of leflunomide and etanercept against the background of experimental rheumatoid arthritis associated with arterial hypertension in rats. Experiments on mature adult, non-linear white rats found that leflunomide and etanercept did not affect the degree of hypertension against the background of adjuvant arthritis, but manifested an antihypertensive effect when used in adjuvant arthritis combined with arterial hypertension. Leflunomide leads to an increase in heart rate by 5–10.4% at different terms of observation, both against the background of adjuvant arthritis only and under the combined pathology conditions. Etanercept, when used against adjuvant arthritis, causes bradycardia but prevents the development of tachycardia, which is detected in untreated animals with a comorbid condition during manifestation and attenuation of the inflammatory process. The study findings may be relevant for development of new approaches to the treatment of rheumatic and cardiac pathology.
    Tags leflunomide, etanercept, cardiotropic action, rheumatoid arthritis, hypertension, comorbid pathology
    Bibliography
    • Gordeyev AV. Multimorbidnaya sreda obitaniya: adalimumab v lechenii patsientov s revmaticheskimi i drugimi soputstvuyushchimi zabolevaniyami. Effektivnaya farmakoter. Revmatol. Travmatol. Ortoped. 2015; 47:34-7. [in Russian]
    • Kovalenko VN, Bortkevich OP, Belyavskaya YuV. Novaya strategiya terapii revmatoidnogo artrita (na osnovanii peresmotra rekomendatsiy Yevropeyskoy antirevmaticheskoy ligi po lecheniyu sinteticheskimi i biologicheskimi bazisnymi bolezn-modifitsiruyushchimi antirevmaticheskimi preparatami. Ukr. Revmatol. zh-l. 2013; 54(4): 97-104. [in Russian]
    • Lineva OG, Popkova TV, Novikova DS, Nasonov YeL. Ingibitory FNO-a i ikh vliyaniye na faktory riska porazheniya serdechno-sosudistoy sistemy u patsientov s revmatoidnym artritom. Nauchno-prakt. Revmatol. 2010; 48(1): 15-9. [in Russian]
    • Nasonov YeL, Popkova TV, Novikova DS. Sovremennyye predstavleniya o patogeneze i osobennosti lecheniya arterialnoy gipertenzii pri revmatoidnom artrite. Ter. Arkhiv. 2011; 5: 24–33. [in Russian]
    • Olyunin YuA. Leflunomid v klinicheskoy praktike. Sovr. Revmatol. 2014; (1): 59-63. [in Russian]
    • Popkova TV, Novikova DS, Nasonov YeL. Kardiovaskulyarnyye faktory riska pri revmaticheskikh zabolevaniyakh: svyaz s vospaleniyem. Cons. Medicum. 2010; 2: 112–8. [in Russian]
    • Popkova TV, Novikova DS, Panasyuk YeYu. Vliyaniye totsilizumaba na sistemu transporta kholesterina krovi i ranniye proyavleniya ateroskleroza u bolnykh revmatoidnym artritom. Ter. Arkh. 2012; 5: 10–8. [in Russian]
    • Udachkina YeV, Novikova DS, Popkova TV, Nasonov Ye.L. Revmatoidnyy artrit i ateroskleroz: rol interleykina-6. Klin. Farmakol. i Terapiya. 2012; 1:  86-92. [in Russian]
    • Bohr DF, Dominiczak AF. Experimantal hypertension. Hypertension. 1991; 17(1): 39–44.
    • McInnes I.B., Schett G. The pathogenesis of rheumatoid arthritis. New Engl Med 2012; 365:2205–19.
    • Singh JA, Furst DE, Bharat A. American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthr. Care Res. 2012; 64 (5): 625–639.
    • Smolen JS, Aletaha D, Redlich K. The pathogenesis of rheumatoid arthritis: new insight from old clinical data? Nat. Rev. Rheumatol. 2012; 8: 235–43.
    • Tanushree R, Saikat G. Animal models of rheumatoid arthritis: correlation and usefulness with human rheumatoid arthritis. Am. J. Pharm. Res. 2013; 3(8): 6131–42.
    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 205-210 pages, index UDK 615.273.55:616-039.811/814
    DOI 10.26724/2079-8334-2020-3-73-205-210