English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Stetsuk Ye.V., Akimov O.Ye., Shepitko K.V., Boruta N.V., Goltsev A.N.

    ROLE OF NITRIC OXIDE IN DEVELOPMENT OF FIBROTIC CHANGES IN RATS’ TESTES AFTER 270 DAY CENTRAL DEPRIVATION OF TESTOSTERONE SYNTHESIS


    About the author: Stetsuk Ye.V., Akimov O.Ye., Shepitko K.V., Boruta N.V., Goltsev A.N.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Disturbance in production of nitric oxide (NO) may lead to various changes in different organs and systems. Certain clinical situations require prolonged usage of inhibitors of testosterone synthesis. Scientific literature provides limited information regarding the influence of prolonged deprivation of testosterone synthesis on production of NO and microscopic organization of rats’ testes. Prolonged central deprivation of testosterone synthesis leads to endothelial dysfunction, development of fibrosis, decreases the nitric oxide production and shifts pro-/antioxidant balance in favor of the pro-oxidants without increase in lipid peroxidation intensity. Central deprivation of testosterone synthesis leads to fibrosis with subsequent disruption of the structural organization of the convoluted seminiferous tubules, hemodynamic disturbances, endothelial dysfunction, increased density of the vascular wall of blood vessels and systemic stasis. Decreased production of NO from constitutive isoforms of NO-synthase plays major role in development of structural changes in the interstitial tissue of testes on the 270th day of the experiment.
    Tags testes; rats; diphereline; oxidative stress; nitric oxide; fibrosis
    Bibliography
    • Bahriy MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Bahriy MM, Dibrova VA. redaktory. Vinnytsya: Nova knyha; 2016. 328s. [in Ukrainian]
    • Boehm M, Novoyatleva T, Kojonazarov B, Veit F, Weissmann N, Ghofrani HA, Seeger W, Schermuly RT. Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis. Am J Respir Cell Mol Biol. 2019; 60(3): 346-356. doi: 10.1165/rcmb.2018-0069OC.
    • Botté MC, Lerrant Y, Lozach A, Bérault A, Counis R, Kottler ML. LH down-regulates gonadotropin-releasing hormone (GnRH) receptor, but not GnRH, mRNA levels in the rat testis. J Endocrinol. 1999; 162(3): 409-415. doi:10.1677/joe.0.1620409.
    • Cameli P, Bergantini L, Salvini M, Refini RM, Pieroni M, Bargagli E, Sestini P. Alveolar concentration of nitric oxide as a prognostic biomarker in idiopathic pulmonary fibrosis. Nitric Oxide. 2019; 89: 41-45. doi: 10.1016/j.niox.2019.05.001.
    • Demirtaş Şahin T, Yazir Y, Utkan T, Gacar G, Furat Rençber S, Gocmez SS. TNF-α antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. Can J Physiol Pharmacol. 2018; 96(2): 200-207. doi:10.1139/cjpp-2017-0113.
    • Iwakiri Y. Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase. Clin Mol Hepatol. 2015; 21(4): 319-25. doi: 10.3350/cmh.2015.21.4.319.
    • Merseburger AS, Hupe MC. An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer. Adv Ther. 2016; 33(7): 1072-93. doi: 10.1007/s12325-016-0351-4.
    • Seo DY, Lee SR, Kwak HB, et al. Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats. Exp Gerontol. 2018; 108: 131-138. doi:10.1016/j.exger.2018.04.003.
    • Stetsuk YeV, Akimov OYe, Shepitko KV, Goltsev AN. Structural organization of stromal and parenchymal components of rat testes during central deprivation of testosterone synthesis on the 180 day of the experiment. World of medicine and biology. 2020; 72(2): 203-207. Doi: 10.26724/2079-8334-2020-2-72-203-207.
    • Tian M, Liu F, Liu H, Zhang Q, Li L, Hou X, Zhao J, Li S, Chang X, Sun Y. Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes. Syst Biol Reprod Med. 2018 Aug;64(4):246-259. doi: 10.1080/19396368.2018.1450460.
    • Yelinska AM, Akimov OYe, Kostenko VO. Role of AP-1 transcriptional factor in development of oxidative and nitrosative stress in periodontal tissues during systemic inflammatory response. Ukr. Biochem. J. 2019; 91(1): 80-85. doi: 10.15407/ubj91.01.080.
    • Yigitturk G, Acara AC, Erbas O, Oltulu F, Yavasoglu NUK, Uysal A, Yavasoglu A. The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomed Pharmacother. 2017; 87: 240-246. doi: 10.1016/j.biopha.2016.12.102.
    • Zhang YH. Nitric oxide signalling and neuronal nitric oxide synthase in the heart under stress. F1000Res. 2017; 6: 742. doi: 10.12688/f1000research.10128.1.
    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 211-215 pages, index UDK 612.0616.31:583.323.7
    DOI 10.26724/2079-8334-2020-3-73-211-215