| About the author: |
Tymoshenko I.O., Cherkasov E.V., Shepitko K.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This work is devoted to the morphometric assesment of structural changes in the duodenal wall of rats with skin burn injury under conditions of experimental diabetes mellitus. The control group included 21 intact animals without any signs of somatic pathology, experimental group I consisted of 21 rats with experimental skin burn injury, experimental group II consisted of 21 rats without skin burns but with experimentally simulated diabetes mellitus, and experimental group III consisted of 21 rats with both skin burn injury and experimentally simulated diabetes mellitus. The following morphometric parameters have been studied: mucosal thickness, villi height and thickness, crypt depth and width, thickness of lamina muscularis of mucosa, submucosa thickness, muscular layer thickness, serosa thickness, height of the epitheliocytes in the middle part of the villi, mitotic index of columnar epitheliocytes. The obtained data confirm the progredient course of changes characteristic of diabetic enteropathy, which gradually worsen after 7, 14 and 21 days of the experiment. |
| Tags |
skin burn injury, streptozotocin-induced diabetes mellitus, duodenal wall, morphometric assessment |
| Bibliography |
- Chaikovsky YuB, Makarova ОІ, Chereshnyuk IL, Lysenko DA. Аcomparative characteristics of cell cycle and dna fragmentation of lung cells in rats after skin burn injury. World of Medicine and Biology. 2014; 2:181-185.
- Cherkasov VG, Kovalchuk AI, Dzevulskaya IV, Malikov AV, Lakhtadyr TV, Matkivskaya RM. Structural transformations in the internal organs with infusion therapy for burn disease. Medical Science of Ukraine. 2015; 11(3-4):4-11.
- Cherkasov VG, Tymoshenko IO. Structural changes of duodenal mucosa enterocytes of rats in burn skin injury under experiment streptozotocin-induced diabetes mellitus. Reports of Morphology. 2019; 25(1):55-61. doi: 10.31393/morphology-journal-2019-25(1)-08
- Dzevulska ІV, Kovalchuk ОІ, Cherkasov EV, Majewskyі ОYe, Shevchuk YuG, Pastukhova et al. Influence of lactoproteinum solution with sorbitol on dna content of cells of endocrine glands on the background of skin burn in rats. World of Medicine and Biology. 2018; 64(2):033-039. doi: 10.26724/2079-8334-2018-2-64-33-39
- Evers LH. The biology of burn injury. Exp. Dermatol. 2010; 19(2),9:777-783. doi: 10. 1111/j.1600-0625.2010.01105.x
- Galunko GM. Histological changes in the small intestine in the advanced stages of burn diseases. World of Medicine and Biology. 2017; 3(61):90-96. doi: 10.26724/ 2079-8334-2017-3-61-90-96
- Gotfried J, Priest S, Schey R. Diabetes and the small intestine. Curr Treat Options Gastroenterol. 2017; 15(4):490-507. doi: 10.1007/s11938-017-0155-x
- Gunas I, Dovgan I, Masur O. Method of intermal burn trauma correction by means of cryoinfluence. Abstracts are presented in zusammen mit der Polish Anatomical Society with the participation of the Association des Anatomistes Verhandlungen der Anatomishen Geselleschaft, Olsztyn Jena-Munchen: Der Urban & Fisher Verlag; 1997. p. 105.
- Gunas IV, Guminskiya YuI, Ocheretna NP, Lysenko DA, Kovalchuk OI, Dzevulska IV, et al. Indicators cell cycle and DNA fragmentation of spleen cells in early terms after thermal burns of skin at the brackground of introduction 0.9% NaCl solution. World of Medicine and Biology. 2018; 1(63):116-120. doi: 10.26.724/2079-8334-2018-1-63-116-120
- Haagsma JA, Greatz N, Bolliger I. The global burden of injury: incidence, mortality, disability – adjusted life years and time trends from the Global Burden of Diseases study 2013. Injury Prevention. 2016; 22(1):3-18.
- Jeschke MG, Pinto R, Kraft R. Inflammation and the Host Response to Injury Collaborative Research Program. Morbidity and survival probability in burn patients in modern burn care. Crit. Care. Med. 2015; 43(2), 4:808-815.
- Kearney L, Francis E C, Clover AJ. New technologies in global burn care - a review of recent advances. Int. J. Burns Trauma. 2018; 8(4):77-87. PMID: 30245912
- Natrus LV, Ryzhko IN, Kozak AI, Kryvosheieva OI, Stechenko LA. Ultrastructural base of the connective tissue skin cells interactions at burn injury in the hyperglycemic white rats. World of Medicine and Biology. 2017; 4(62):157-162. doi: 10.26724/2079-83342017-4-62-157-162
- Regas FC, Ehrlich HP. Elucidating the vascular response to burns with a new rat model. J. Trauma. 1992; 32(5):557-563.
- Smolle Ch, Cambiaso-Daniel J, Forbes AA. Recent trends in burn epidemiology woredwide: A systemic review. Burns. 2017; 43(2):249-257.
|
| Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 215-219 pages, index UDK 616.342.018.25-091:616.5-001.17.:616.379-08.64:57.084. |
| DOI |
10.26724/2079-8334-2020-3-73-215-219 |
