English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Tymchenko M.Ye., Ivanova Yu.V., Gramatiuk S.M., Zarutskyi Ya.L., Bilyi V.Ya.

    MICROENVIRONMENT OF INTESTINAL ANASTOMOSES WITH COMPARATIVE ASSESSMENT OF IMMUNE STATUS IN PATIENTS WITH SMALL INTESTINE ANASTOMOSES


    About the author: Tymchenko M.Ye., Ivanova Yu.V., Gramatiuk S.M., Zarutskyi Ya.L., Bilyi V.Ya.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The purpose of the study was to assess local immune status as a marker for the risk of intestinal anastomosis failure. The research was based on the study of local immune mechanisms of intestinal anastomoses failure in the comparative aspect. The material of the study was the anastomosis tissue, areas of the intestine at a distance of 1-3 cm from the anastomosis, as well as the patients’ blood samples taken before surgery, on the first and the fifth days after the formation of the anastomosis in subgroups of the study. The occurrence of intestinal anastomoses failure is mainly determined by the interaction of immunocompetent cells and products of their activity - cytokines. Immunological disorders in the intestine tissues in the anastomosis area cause the failure pathogenesis. The microenvironment of intestinal anastomoses by immunological parameters is a field that promotes further progression of inflammation or serves as a buffer zone that protects tissue from pathological changes. The study revealed the formation of secondary immune deficiency in patients with resection of intestinal segments; recovery of immune status indices in patients with uncomplicated postoperative period occurs at an earlier date and to the fuller extent.
    Tags intestinal anastomoses, failure, immunology
    Bibliography
    • Kaminskiy IV, Chemodanov YeB. Kliniko-eksperimentalnoye obosnovaniye primeneniya pretsizionnogo kishechnogo shva u bolnykh s vysokoy stepenyu veroyatnosti vozniknoveniya posleoperatsionnykh oslozhneniy. Ukrayinskyi zhurnal khirurhiyi. 2014; 1(24):86-93.Dostupno na: http://www.mif-ua.com. [in Russian]
    • Ksyonz IV, Kharchenko DA, Ksyondz VI. Krioadaptatsiya sehmentiv kyshky pry nakladanni anastomozu u khvorykh z kyshkovoyu neprokhidnistyu pukhlynnoho henezu. Svit medytsyny ta biolohiyi. 2019; 2(68):79-82 DOI: https://doi.org/10.26724/2079-8334-2019-2-68-82-85[in Ukrainian]
    • Mylytsya MM, Anhelovskyi IM, Postolenko MD, Soldusova VV. Profilaktyka nespromozhnosti tovstokyshkovykh anastomoziv pry obturatsiyniy neprokhidnosti. Shpytalna khirurhiya. Zhurnal imeni L. Ya. Kovalchuka. 2016; 4:11-13 DOI:https://doi.org/10.11603/2414-4533.2016.4.7176 [in Ukrainian]
    • Minnullin MM, Abdulyanov AV, Nikolayev YaYu. Khirurgicheskaya taktika pri ranney posleoperatsionnoy spayechnoy kishechnoy neprokhodimosti. Prakticheskaya meditsina.2014;Том 2,4:77-81. [in Russian]
    • Perepadya SV, Zhukov VI, Zaytseva OV, Moiseyenko AS, Perepadya OV. Issledovaniye neyrokhimicheskikh aspektov obmena mediatornykh aminokislot u bolnykh kolorektalnym rakom. Problemy ekolohiyi ta medytsyny. 2010;1-2:25-7. [in Russian]
    • Sukhodolya AI, Nazarchuk SA, Dmytriyev DV. Obhruntuvannya zastosuvannya ksenodermoimplantativ dlya profilaktyky nespromozhnosti kyshechnykh shviv ta anastomoziv v onkokhvorykh u krytychnomu stani. Bil, znebolyuvannya i intensyvna terapiya. 2015;3:44-51 DOI: https://doi.org/10.25284/2519-2078.3(72).2015.84590. [in Ukrainian]
    • Barone M, Licinio R, Amoruso A, Viggiani MT, Larocca AM, Di Leo A. Lesson from an intriguing case of cryoglobulinemia. World J Gastroenterol. 2013 Jan 14; 19(2):304-6. DOI: https://doi.org/10.3748/wjg.v19.i2.304.
    • Desbois AC, Cacoub P, Saadoun D. Cryoglobulinemia: An update in 2019. Joint Bone Spine. 2019 Nov; 86(6):707-713. DOI: https://doi.org/10.1016/j.jbspin.2019.01.016.
    • Mazzaro C, Maso LD, Mauro E, Gattei V, Ghersetti M, Bulian P, Moratelli G, Grassi G, Zorat F, Pozzato G. Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases. Diseases. 2018 May 3; 6(2). DOI: https://doi.org/10.3390/diseases6020035.
    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 220-224 pages, index UDK 616.34-089.843-612.398.132-02
    DOI 10.26724/2079-8334-2020-3-73-220-224