| About the author: |
Fik V.B., Paltov Ye.V., Kryvko Yu.Ya. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In the experiment on white rats, ultrastructural studies of periodontal tissues were carried out against the background of twelve-weeks opioid action. Animals were subjected to intramuscular injections of an opioid analgesic with a gradual increase in the mean single dose every two weeks. The initial dose was 0.212 mg/kg, and within 11–12 weeks the dose was increased up to 0.3 mg/kg. The results of submicroscopic studies have revealed the progression of chronic sclerosing inflammation in the periodontium and the development of regenerative-plastic deficiency of epitheliocytes, endothelial cells and the periodontium structural components, which was caused by a long-term opioid action. |
| Tags |
periodontium, rat, opioid, ultrastructure |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 234-237 pages, index UDK 611.311.018.73:615.214.24].08:616-076.4 |
| DOI |
10.26724/2079-8334-2020-3-73-234-237 |
