| About the author: |
O.L. Appelhans, К.М. Usychenko, Yu.I. Bazhora, О.M. Usychenko |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to assess the possibility of the relationship between the gene polymorphism of SMAD family member 7 (SMAD7C> T), the eukaryotic translation initiation factor (eIF3hC> A) and the degree of liver fibrosis in a pilot project in patients with chronic hepatitis B and chronic hepatitis C. Differences in the frequencies of alleles of the SMAD7 gene in the ethnically homogeneous group of residents of the Odessa region in patients with chronic hepatitis C and chronic hepatitis B compared to healthy individuals (p <0.05) were found. The presence of correlations was established: in patients with chronic hepatitis C, there is a direct weak correlation between the degree of fibrosis and SMAD7 genotypes (p <0.01); in patients with chronic hepatitis B, there is a direct strong correlation between the fibrosis degree and SMAD7 genotypes (p <0.01). The correlation between the degree of liver fibrosis and certain genotypes of SMAD7 in patients with chronic hepatitis C and chronic hepatitis B permits to use the information obtained as one of the criteria for the rate of fibrotic processes progression in the liver. |
| Tags |
SMAD family member 7, eukaryotic translation initiation factor eIF3h, chronic hepatitis C, chronic hepatitis B |
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| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 7-10 pages, index UDK 616.36-002.2 575.174.015.3. |
| DOI |
10.26724/2079-8334-2020-4-74-7-10 |
