| About the author: |
R.S. Vastyanov, A.N. Stoyanov, Yu.S. Krepec, A.F. Dzygal, Ya.V. Beseda, A.V. Puchkova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the work is to study the chronic convulsive activity intensity in conditions of picrotoxin-induced kindling and due to recombinant antagonist of interleukin-1 receptors introduction as well as registration of electrographic activity of brain structures and investigation of electrical potentials generated by subcortical structures in conditions of recombinant antagonist of interleukin-1 receptors administration. The experimental data are given showing the anticonvulsive action after recombinant antagonist of interleukin-1 receptors intraperitoneal, intracerebral administrations. Recombinant antagonist of interleukin-1 receptors intrahippocampal, intranigral and intracerebroventricular microinjections resulted in anticonvulsive efficacy expressed mainly by seizure intensity decreasing. The most pronounced anticonvulsive effects were obtained after recombinant antagonist of interleukin-1 receptors intracerebroventricular microinjection which additionally characterized by the first seizure reactions latency increase and the number of rats with tonic-clonic seizures decrease. Less expressed anticonvulsive efficacy was registered in case of recombinant antagonist of interleukin-1 receptors both intrahippocampal and intranigral administrations. The authors conclude about the principal possibility of the anticonvulsive efficacy realization after recombinant antagonist of interleukin-1 receptors intraperitoneal and intracerebral administrations in conditions of experimental chronic epileptogenesis. |
| Tags |
kindling, ventral hippocampus, black substance, cerebral ventricles, recombinant interleukin-1 receptors antagonist, anticonvulsive effect |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 168-174 pages, index UDK 612.017.1:612.8.062;612.821.7+616.853 |
| DOI |
10.26724/2079-8334-2020-4-74-168-174 |
