| About the author: |
L.S. Kravchenko, O.L. Appelhans, A.Ye. Polyakov, О.V. Pasechnik, S.V. Shcherbakov |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Biochemical changes in the blood serum, liver and gingival tissue were examined during simulation of the metabolic syndrome of alimentary genesis in experiment on 28 white male rats of reproductive age with an average body weight (280±14) g. It was found that keeping animals for ten weeks on a diet high in saturated fats and carbohydrates led to increase in body weight and in level of biochemical markers: insulin resistance, hyperglycemia, inflammation, both at the level of the body and locally in the periodontal tissues. Local application of the new dental elixir in the form of applications to rats gums against the background of metabolic syndrome reduced the level of triglycerides, had an anti-inflammatory and antioxidant effect, reducing contamination by pathogenic microflora (urease activity), lipid peroxidation activity (malonic dialdehyde content), activating locally in the periodontal tissues the antioxidant defense enzyme and nonspecific immunity – lysozyme. |
| Tags |
metabolic syndrome of gingival tissue, inflammation, treatment, dental elixir |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 179-183 pages, index UDK 618.311.2:616.314.16/17-08:615.27:616-008.9 |
| DOI |
10.26724/2079-8334-2020-4-74-179-183 |
