| About the author: |
V.M. Semenova, V.I. Tsymbalyuk, L.D. Liubich, D.M. Egorova, L.P. Stayno, O.V. Shevchuk, V.V. Vaslovich, S.A. Verbovska, O.G. Deryabina, N.S. Shuvalova, L.D.Pichkur |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In the chronic course of experimental allergic encephalomyelitis neurodegenerative changes in the brain tissue of rats exacerbate within 2 months. Suboccipital administration of mesenchymal stem cells obtained from human umbilical cord (1×106) and cryopreserved in the solution containing 3% dimethyl sulfoxide, 15% ethylene glycol, 10% sucrose, 12% trehalose, and 60% fetal calf serum inhibits these changes in hippocampus (day 35); administration of those cryopreserved in the solution containing 4% dimethyl sulfoxide, 6% trehalose, and 90% fetal calf serum inhibits these changes in both hippocampus (days 35-60) and brain cortex (day 60); administration of these cells cryopreserved in the solution containing 10% dimethyl sulfoxide and 90% fetal calf serum slows down the changes in hippocampus (days 35-60) and partly recover the neuronal component in the brain cortex (day 60). |
| Tags |
mesenchymal stem cells from human umbilical cord, suboccipital administration, brain cortex, hippocampus, pathologically changed neurons, demyelination |
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| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 199-204 pages, index UDK 591.481.1:616.832-002-056.3:591.8:612.014.43:616-092.9 |
| DOI |
10.26724/2079-8334-2020-4-74-199-204 |
