| About the author: |
Ye.V. Stetsuk, O.Ye. Akimov, V.I. Shepitko, A.N. Goltsev |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Some testicular diseases require long-term use of testosterone synthesis blockers. It is known that testosterone is a necessary component for the physiological cooperation of cell forms of the stroma and parenchyma of testes. The scientific literature contains a limited amount of data about the effect of long-term deprivation of testosterone synthesis on this cooperation. The aim of our study was to establish the effect of long-term (365 days) inhibition of hypothalamic-pituitary stimulation of spermatogenesis on morphological and biochemical parameters in rat testes. Central deprivation of testosterone synthesis leads to fibrosis with subsequent disruption of the structural organization of the convoluted seminiferous tubules, hemodynamic disorders, endothelial dysfunction, increased density of blood vessel walls and systemic congestion. A decrease in the activity of constitutive NO synthase isoforms plays a major role in the development of structural changes in the testes of rats. |
| Tags |
testes, interstitial endocrinocytes, sustentocyte, NO-synthase, iNOS, cNOS, L-arginine, superoxide dismutase, rats, fibrosis |
| Bibliography |
- Bahriy MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Bahriy MM, Dibrova VA, redaktory. Vinnytsya: Nova knyha; 2016. 328s. [in Ukrainian]
- Palatova TV, Maslyakova GN, Bucharskaya AB, Medvedeva AV, Voronina ES. Morfologicheskaya kharakteristika yaichek ploda pri khronicheskoy vnutriutrobnoy gipoksii v razlichnyye periody gestatsii. Arkh Patol. 2018; 80(4): 21-26. doi: 10.17116/patol201880421. [In Russian]
- Almeida S, Rato L, Sousa M, Alves MG, Oliveira PF. Fertility and Sperm Quality in the Aging Male. Curr Pharm Des. 2017; 23(30): 4429-4437. doi: 10.2174/1381612823666170503150313.
- Botté MC, Lerrant Y, Lozach A, Bérault A, Counis R, Kottler ML. LH down-regulates gonadotropin-releasing hormone (GnRH) receptor, but not GnRH, mRNA levels in the rat testis. J Endocrinol. 1999; 162(3): 409-415. doi:10.1677/joe.0.1620409.
- Cheng J, Yang HL, Gu CJ, Liu YK, Shao J, Zhu R, He YY, Zhu XY, Li MQ. Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF. Int J Mol Med. 2019; 43(2): 945-955. doi: 10.3892/ijmm.2018.4021.
- Felemban SG, Aldubayan MA, Alhowail AH, Almami IS. Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats. Oxid Med Cell Longev. 2020; 2020: 4372719. doi: 10.1155/2020/4372719.
- Hreha TN, Collins CA, Daugherty AL, Griffith JM, Hruska KA, Hunstad DA. Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring. Front Immunol. 2020; 11: 1641. doi: 10.3389/fimmu.2020.01641.
- Indumathy S, Pueschl D, Klein B, Fietz D, Bergmann M, Schuppe HC, Da Silva N, Loveland BE, Hickey MJ, Hedger MP, Loveland KL. Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels. J Reprod Immunol. 2020; 142: 103204. doi: 10.1016/j.jri.2020.103204.
- Merseburger AS, Hupe MC. An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer. Adv Ther. 2016; 33(7): 1072-93. doi: 10.1007/s12325-016-0351-4.
- Nahomi RB, Nagaraj RH. The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells. J Cell Biochem. 2018; 119(8): 6814-6827. doi: 10.1002/jcb.26877.
- Palladino MA, Fasano GA, Patel D, Dugan C, London M. Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis. Basic Clin Androl. 2018; 28: 14. doi: 10.1186/s12610-018-0079-x.
- Shore ND, Morgans AK, Ryan CJ. Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in Prostate Cancer. Clin Genitourin Cancer. 2020: S1558-7673(20)30198-1. doi: 10.1016/j.clgc.2020.08.008.
- Stetsuk YeV., Akimov OYe., Shepitko KV., Goltsev AN. Morphofunctional features of rat testes interstitial endocrinocytes and sustentocytes after 90 days of central testosterone synthesis deprivation. World of Medicine and Biology. 2020; 1(71): 226-231. doi: 10.26724/2079-8334-2020-1-71-226-231.
- Stetsuk YeV, Akimov OYe, Shepitko KV, Goltsev AN. Role of nitric oxide in development of fibrotic changes in rats’ testes after 270 day central deprivation of testosterone synthesis. World of medicine and biology. 2020; 73(3): 211-215. doi: 10.26724/2079-8334-2020-3-73-215-219.
- Wenjing Y, Li L, Xiaofeng H, Guanghan K, Lifang L, Jishuai C, Chen X, Wei S, Wei C, Shanmin Z,1 and Shufang C. Levels of Leydig cell autophagy regulate the fertility of male naked mole-rats. Oncotarget. 2017 Nov 17; 8(58): 98677–98690. doi: 10.18632/oncotarget.22088.
|
| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 210-214 pages, index UDK 612.0616.31:584.345.9 |
| DOI |
10.26724/2079-8334-2020-4-74-210-214 |
