| About the author: |
D. V. Shamrai, N. O. Melnyk |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Ovarian cancer is a principal cause of death and accounts for 25% among all gynecological tumors. The aim of this study is to establish efficacy of hormonal treatment for precancerous conditions in rats’ ovaries. We used modified Biskind’s method and made intramuscular injections of gonadotropin-releasing hormone agonist for precancerous conditions treatment. We described morphological changes in rats’ ovaries in different terms of hormonal treatment. Thus, from the 30th day, this leads to total hydropic degeneration of ovarian cells or atrophy of the ovary. From the 60th day the treatment is still effective, however we can observe collection of luteal cells with normal cytoplasm. From the 90th day, it is no longer effective and doesn’t lead to degeneration of cells, we observe follicular and lutein elements in the ovary with cellular atypism signs. Thus, from the 90th day, the ovarian tissue becomes resistant to hormonal influence and the treatment is ineffective. |
| Tags |
precancerous conditions, ovary, Biskind`s model, hormonal therapy, gonadotropin-releasing hormone agonist, sex-cord tumor |
| Bibliography |
- Vorobyova І.І., Gyvetska А.А., Denysova V.B. Nevunoshuvanna vagitnosti: suchasni poglyadu na problemu. Zdorovye genshiinu. 2017;3:113-7. [in Russian]
- Manuhin I.B. Ginekologicheskaya endokrinologiya. Klinicheskie lekcii/I. B. Manuhin, M. A. Gevorkyan, E. I. Manuhina. M.:GEOTAR-Media. 2019; 304 p. [in Russian]
- Serov V.N. Racionalnaya farmakoterapiya v akusherstve, ginekologii i neonatologii. Tom 1. Akusherstvo, neonatologiya: rukovodstvo/pod obshej red. V.N. Serova, G.T. Suhih. M.: Litterra. 2010.784 p. [in Russian]
- Shamrai D. V., Melnyk N.O. Peredpuhlinni zmini v yayechniku shuriv cherez 223 dobi pislya operaciyi za metodikoyu Biskind u modifikaciyi/ D.V. Shamraj. Naukovij visnik NMU imeni O.O. Bogomolcya. Kyiv. 2012;2 (37):120 p. [in Ukrainian]
- Biskind MS, Biskind GR. Development of tumors in the rat ovary after transplantation into the spleen. Proc. Soc. Exp. Biol. Med. 1944;55:176 р.
- Bulletin of National Cancer Registry of Ukraine, vol.17, 2014-2015 www.ncru.inf.ua/publications/BULL_17/index_e.htm
- Cui J, Miner BM, Eldredge JB. Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation. BMC Cancer. 2011; 11:280.
- Filipp Dzh, Disaya Uilyam T. Krisman Klinicheskaya onkoginekologiya. Moskva: Rid Elsiver, 2011;316 p.
- Liu N, Wang X, Sheng X. The clinicopathological characteristics of triplenegative’ epithelial ovarian cancer. J. Clin. Pathol. 2012; 63:240-243.
- Ling Poon S, Lau MT, Hammond GL. Gonadotropinreleasing hormoneII increases membrane type I metalloproteinase production via betacatenin signaling in ovarian cancer cells. Endocrinology. 2011;152(3):764-72.
- NCCN Clinical Practice Guidelines in Oncology Ovarian (2.2011) Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer. Version 2.2011.
|
| Publication of the article |
«World of Medicine and Biology» №4(74), 2020 year, 215-219 pages, index UDK 618.11-006.04-092.001.57 |
| DOI |
10.26724/2079-8334-2020-4-74-215-219 |
