R. S. Vastyanov, O. M. Stoyanov, O. M. Platonova, P. P. Yermuraki, I. O. Ostapenko, S. V. Tatarko, V. O. Bibikova

PATHOGENETIC MECHANISMS OF CONVULSIVE DEPRESSIVE SYNDROME IN THE CONDITIONS OF KINDLING-INDUCED MODEL OF EPILEPTOGENESIS

---

About the author:	R. S. Vastyanov, O. M. Stoyanov, O. M. Platonova, P. P. Yermuraki, I. O. Ostapenko, S. V. Tatarko, V. O. Bibikova
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	Non-convulsive behavioral disorders are registered in the majority (over 75 %) of patients with epilepsy and are most often the only and most prominent manifestation of this disease. However, the neuropathogenetic mechanisms of these behavioral disorders remain insufficiently studied in the dynamics of chronic epileptogenesis, and the question of pathogenetically determined correction of non-convulsive epileptiform behavioral disorders is not considered in terms of comprehensive treatment of the chronic convulsive syndrome. The purpose of our work was to study the dynamics of the postural behavior severity in rats under the conditions of different periods of formation of picrotoxin-induced kindling using the striatal functional activity modulation. The obtained data indicate the hyperactivation of the striatum under the conditions of the development of picrotoxin-induced chronic convulsive activity, which functional activity depends on the term of the convulsive syndrome manifestation. The study of non-convulsive types of motor, emotional, swimming, cognitive behavior and their disorders during the specified time intervals of the formation of chronic epileptic activity is important for the use of certain behavioral disorders as an early diagnosis of epilepsy when the motor seizure disorders are absent and the probable behavior disorders do not reach maximum intensity
Tags	kindling, postkindling, picrotoxin, non-convulsive behavioral disorders, postural behaviour, striatum, striatal neurotransmitter systems
Bibliography	Avakyan GN. Voprosy sovremennoy epileptologii. Epilepsiya iparoksizmalnyie sostoyaniya. 2015; 7 (4): 16–21. [In Russian] Vastyanov RS, Topal MM, Stoyanov OM, Broshkov MM, Galuzinska MI, Levkovska VYu, Shpota OE. Neyrofarmakolohichniy analiz modulyatsiyi aktyvnosti khvostatoho yadra pry khronichniy sudomniy aktyvnosti. Svit meditsini ta biologiyi.2019; 1: 126–133. [in Ukrainian] Godlevskiy LS, Kobolev EV, Mustyatsa VF, Drozdova GA. Modelirovanie i mekhanizmy podavleniya eksperimentalnogo epilepticheskogo sindroma. Odesa: KP OGT; 2010. 350 s. [In Russian] Leontyev OV, Kruglova MA, Kruglov VA, Dergunov AV. Patofiziologiya nervnoy sistemy. Leontyev OV. redactor. S-Pb: SpetcLit; 2019. 150 s. [In Russian] De Vries HE, Kooij G, Frenkel D, Georgopoulos S, Monsonego A, Janigro D. Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease. Epilepsia. 2012; 53(6): 45–52. Lukasiuk K, Pitkänen A. Molecular basis of acquired epileptogenesis. Handb.Clin. Neurol. 2012; 107: 3–12. Photographic Atlas of the Rat Brain the Cell and Fiber Architecture Illustrated in Three Planes With Stereotaxic Coordinates: A Photographic Guide to the Cell and Fiber Architecture of the Rat Brain Illustrated in Three Planes With Stereotaxic Coordinates. Kruger L, Saporta S, Larry W, editors. Cambridge: University Press; 1995. 299 p. PostRM. Progressive changes in behavior and seizures following chronic cocaine administration: relationship to kindling and psychosis. Cocaine and other stimulants. Ellinwood EH Jr, Kilbey MM, editors. New York, Plenum Press. 1977; 3: 353–372. Sankar R, Mazarati A. Neurobiology of Depression as a Comorbidity of Epilepsy. Jasper's Basic Mechanisms of the Epilepsies. Bethesda: NationalCenter for Biotechnology Information. 2012. 207–233. Van Luijtelaar G, Lyashenko S, Vastyanov R, VerbeekG, Oleinik A, Van Rijn I et al. Cytokines and absence seizures in a genetic rat model. Neurophysiology. 2012; 43 (6): 478–486.
Publication of the article	«World of Medicine and Biology» №1(75), 2021 year, 181-186 pages, index UDK 616.8-009.12-008.6-036.12-06:616.89-008.454]-092
DOI	10.26724/2079-8334-2021-1-75-181-186