| About the author: |
O. Yu. Kushnir, I. M. Yaremii, O. I. Petryshen |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This study investigated the possible protective effects of melatonin as an antioxidant against alloxan-induced diabetic kidney injury in rats. The introduction of melatonin to alloxan diabetic rats is conducive to a decrease in them of the level of basal glycemia, as well as – a stabilization of the indices of the body’s antioxidant defense disturbed namely activities of glutathione reductase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, content of malonic dialdehyde and glutathione in rats kidney. Melatonin not only neutralizes reactive oxygen species, but also acts through the stimulation of several antioxidative enzymatic systems in kidney of alloxan diabetic rats. |
| Tags |
antioxidative system, melatonin, alloxan diabetes, kidney, rats |
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| Publication of the article |
«World of Medicine and Biology» №1(75), 2021 year, 193-196 pages, index UDK 577.17:612.826.33:616.379-008.64]-092.9 |
| DOI |
10.26724/2079-8334-2021-1-75-193-196 |
