| About the author: |
T. O. Kryuchko, I. M. Nesina, L. M. Bubyr, O. Ya. Tkachenko, O. A. Poda, N. V. Kuzmenko, L. Yu. Kryvoshapka |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This article presents diagnostically significant relationships between cytokine status indicators and specific morphological criteria that characterize the condition of the mucosa of the upper gastrointestinal tract in children with gastrointestinal manifestations of food hypersensitivity. Comparative analysis of pathomorphological changes in inflammatory processes of the lining of the stomach and the duodenum demonstrates that children with IgE-dependent gastrointestinal symptoms of food allergy had a more pronounced degree of inflammatory infiltration with high content of eosinophils, as well as dystrophic changes of glandular epithelium and marked stromal edema. Cytokine imbalance in the form of increased interleukin-4 and TARC/CCL-hemokine, along with decreased anti-inflammatory interleukin-10, showed a clear correlation with specific histological changes in the form of eosinophilic infiltration of the gastric mucosa, which allows us to identify specific immunological markers of food allergy. |
| Tags |
children, food hypersensitivity, gastroduodenal pathology, interleukin-4, interleukin-10, TARC/CCL-17 chemokine |
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| Publication of the article |
«World of Medicine and Biology» №2(76), 2021 year, 069-073 pages, index UDK 616.33./34-002-085 |
| DOI |
10.26724/2079-8334-2021-2-76-69-73 |
