| About the author: |
V. G. Lyzogub, O. M. Savchuk, O. G. Kupchynska, T. M. Motsak |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In 62 patients with multifocal atherosclerosis of men of average age (72.3±3.3) years, blood flow parameters in peripheral arteries, serotonine, histamine, dophamine, beta–endorphins in serum and serotonine in plasma. Found a significant decrease in volumetric blood flow in the arteries carotis interna, mesenterica superior, femoralis communis, tibialis posterior; the levels of serotonine, histamine, dophamine in the serum significantly exceeded their maximum values of almost healthy individuals (control group, n=19), respectively, 4.6, 4.3 and 3.5 times. Taking cilostazol for 12 weeks contributed to a significant (p<0.001) increase in volumetric blood flow in the studied arteries: – in arteries carotis interna by 18.2 %, in arteria mesenterica superior – by 17.8 %, in arteria femoralis communis – by 18.8 %, in arteria tibialis posterior – by 69.4 %, which was accompanied by an improvement in the clinical manifestations of the disease, a significant decrease plasma serotonine level (by 2.9 times; p<0.001) and serotonine (by 39.0 %; p<0.05) and histamine (by 62.1 %; p<0,01) in blood serum, increase beta–endorphin level (by 29.8 %; p<0,01). Serum dophamine levels did not change significantly. The role of neurotransmitters in the course of multifocal atherosclerosis is discussed; the pharmacotherapeutic possibilities of cilostazol are analyzed. |
| Tags |
multifocal atherosclerosis, serotonine, histamine, dopamine, b-endorphin, hemodynamics, cognitive function, myocardial ischemia |
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| Publication of the article |
«World of Medicine and Biology» №2(76), 2021 year, 074-078 pages, index UDK 616.13-004.6-092+615.22 |
| DOI |
10.26724/2079-8334-2021-2-76-74-78 |
