| About the author: |
O. S. Khukhlina, Z. Ya. Kotsyubiychuk, A. A. Antoniv, O. Ye. Mandryk, O. S. Voyevidka |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
75 patients with non-alcoholic steatohepatitis with comorbid type 2 diabetes mellitus and stage I-IV diabetic kidney disease were examined in the treatment dynamics. It was found that the comorbid course of non-alcoholic steatohepatitis and diabetic kidney disease in patients with type 2 diabetes is accompanied by a significant increase in the intensity of oxidative stress, accompanied by an increase in blood intermediate and final products of lipid peroxidation and oxidative modification of proteins in the range of 1.9-2 times (p <0.05). The damaging effect of oxidative stress in patients with type 2 diabetes leads to activation of hepatocyte apoptosis with an increase in blood cytokeratin-18 (7.5 times, p <0.05), the content of which correlates with the degree of oxidative stress, the intensity of liver damage and the stage of diabetic kidney disease (p <0.05). Оxidative stress increases the risk of endothelial damage by atherosclerotic process due to hyperproduction of homocysteine (3.9 times, p <0.05), which contributes to the progression of diabetic kidney disease. The use of Quercetin in the complex therapy of non-alcoholic steatohepatitis and type 2 diabetes with diabetic kidney disease contributes to a probable decrease in the intensity of oxidative stress, increased activity of antioxidant protection factors (content of reduced glutathione in erythrocytes, glutathione peroxidase activity, catalase). 1.7 times) and endothelial damage (reduction of homocysteine in the blood by 1.9 times) (p <0.05). |
| Tags |
non-alcoholic steatohepatitis, type 2 diabetes mellitus, diabetic kidney disease, apoptosis, atherosclerosis, quercetin |
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| Publication of the article |
«World of Medicine and Biology» №3(77), 2021 year, 175-178 pages, index UDK 616.36-003.826-06:616.61-02:616.379-008.64]-036.1-08-039.76 |
| DOI |
10.26724/2079-8334-2021-3-77-175-178 |
