| About the author: |
N. M. Rozhkovska, I. Z. Gladchuk, I. A. Kobylyanska, L. G. Rosha, A. O. Gavrilyuk, D. S. Sukhan, A. L. Kostjuk |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Endometrial cysts occupy one of the leading positions among endometrial neoplasms (up to 30 % of women of reproductive age have a history of this disease). The purpose of the study was to evaluate the immunomorphological features of ovarian endometrial tissue in women with infertility to assess their prognostic and diagnostic value. Our study has shown lower levels of estrogen and progesterone receptors in eutopic endometrium in women with ovarian endometrial cysts than in women without genital pathology. We associate this with the expression variants of the ER and PR receptor systems. In the main group, this ratio was 1 (11 out of 50 women had a characteristic histochemical picture for this pathology); in the comparison group, this figure was 14 cases out of 50, and in the control group – in 18 patients out of 50 studied. This allows us to consider the problem of sex hormones dysregulation as a predictor and, at the same time, a potential point of influence on the pathogenesis of cysts of endometrial origin. |
| Tags |
endometrial cyst, infertility, estrogen receptor, progesterone receptor |
| Bibliography |
- Afinogenova EA, Cherstvyj ED. Aktivnyi i neaktivnyi adenomioz: sravnitelnyi analiz v ochagakh ektopicheskogo endometriya (ekspressiya aromatazy Р-450, retseptorov estrogenov A i V, retseptorov progesterona). Vestnik obrazovaniya i razvitiya nauki Rossiyskoy akademii yestestvennykh nauk. 2016; 20(2): 74–82. [in Russian]
- Benyuk VO, Goncharenko VM. Individualizacziya likuvannya zhinok reproduktivnoho ta premenopauzalnoho viku z giperplastichnym i protsesamy endometriyu. Zdorovye zhenshchiny. 2014; 10(96): 125–129. [in Ukrainian]
- Honcharenko HIu. Rol estrohenovykh i prohesteronovykh retseptoriv u zhinok z adenomiozom u postmenopauzi. Visnyk Vinnytskoho natsionalnoho medychnoho universytetu. 2019; 23(1): 148–152. doi: 10.31393/reports-vnmedical-2019-23(1)-26. [in Ukrainian]
- Kolotovkina AV, Kalinina EA, Kohan EA. Morfofunktsyonalnye osobennosti endometryia u bolnykh endometryoz assotsiirovannym besplodiem (obzor literatury). Konsilium medikum. 2012; 4: 74–79. [in Russian]
- Kuryk OH, Kalenska OV. Imuhistokhimichne doslidzhennia hormonalnoyi aktyvnosti ektopichnoho i eutopichnoho endometriya pry adenomiozu. Naukovyi zhurnal MOZ Ukrayiny. 2014; 1(5): 100–105. [in Ukrainian]
- Meliksetyan AV, Kuryk OG, Kalenska OV, Lysenko BM. Imunohistokhimichne doslidzhennia retseptoriv estrohenu i prohesteronu u vohnyshchakh henitalnoho endometriozu. Ukrayinskyi naukovo-medychnyi molodizhnyi zhurnal. 2014; 3(82): 71–73.[in Ukrainian]
- Feng Z, Wen H, Ju X, Bi R, Chen X, Yang W, et al. Hormone receptor expression profiles differ between primary and recurrent high-grade serous ovarian cancers. Oncotarget. 2017; 8(20): 32848–32855. doi: 10.18632/oncotarget.15858.
- Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, Crețoiu SM, et al. Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina (Kaunas). 2020; 56(9): 460. doi: 10.3390/medicina56090460.
- Fitzgibbons PL, Bartley AN, Connolly JL. Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Breast. College of American Pathologists. 2018; 1–15.
- Gibson DA, Simitsidellis I, Collins F, Saunders PTK. Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders. Int J Mol Sci. 2018; 19(10): 3276. doi: 10.3390/ijms19103276.
- Gómora MJ, Morales-Vásquez F, Pedernera E, Perez-Montiel D, López-Basave H, Villa AR, et al. Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women. Endocr Connect. 2018; 7(9): 1006–1012. doi: 10.1530/EC-18-0158.
- Johnson NP, Hummelshoj L, Adamson GD, Keckstein J, Taylor HS, Abrao MS, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017; 32: 315–324. doi: 10.1093/humrep/dew293.
- Oehmke F, Suwandinata F, Deisting C, Tinneberg H. Datenlage zur Endometriose. Der Gynäkologe. 2007; 40(7): 521–526 doi:10.1007/s00129-007-2015-6.
- Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975; 122(2): 262–263. doi: 10.1016/s0002-9378(16)33500-1.
- Yamamoto K, Mitsuhashi Y, Takaike T, Takase K, Hoshiai H, Noda K. Tubal endometriosis diagnosed within one month after menarche: a case report. Tohoku J Exp Med. 1997; 181(3): 385–387. doi: 10.1620/tjem.181.385.
|
| Publication of the article |
«World of Medicine and Biology» №4(78), 2021 year, 141-145 pages, index UDK 618.11-006:577.275.6-055.2(045) |
| DOI |
10.26724/2079-8334-2021-4-78-141-145 |
